Results 101 to 110 of about 617,738 (364)

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects

open access: yesNutrients, 2018
There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between taste perception and taste ...
R. Barragán   +10 more
semanticscholar   +1 more source

The Representation of Umami Taste in the Taste Cortex [PDF]

open access: yesThe Journal of Nutrition, 2000
To investigate the neural encoding of glutamate (umami) taste in the primate, recordings were made from taste-responsive neurons in the cortical taste areas in macaques. Most of the neurons were in the orbitofrontal cortex (secondary) taste area. First, it was shown that there is a representation of the taste of glutamate that is separate from the ...
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Ambient air pollution undermines chemosensory sensitivity – a global perspective

open access: yesScientific Reports
This study offers insights into the complex relationship between chemical species constituting air pollution and chemosensory function. We examined the relationship between chemical species known to contribute to air pollution and assault human health ...
Anna Oleszkiewicz   +3 more
doaj   +1 more source

Taste Quality Representation in the Human Brain

open access: yesJournal of Neuroscience, 2019
In the mammalian brain, the insula is the primary cortical substrate involved in the perception of taste. Recent imaging studies in rodents have identified a “gustotopic” organization in the insula, whereby distinct insula regions are selectively ...
Jason A. Avery   +5 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Taste bud

open access: yes, 2005
Human taste bud with underlying neural ...

core  

Towards an Electronic Dog Nose: Surface Plasmon Resonance Immunosensor for Security and Safety

open access: yesSensors, 2014
This review describes an “electronic dog nose” based on a surface plasmon resonance (SPR) sensor and an antigen–antibody interaction for security and safety.
Takeshi Onodera, Kiyoshi Toko
doaj   +1 more source

Recent advances in the genetic basis of taste detection in Drosophila

open access: yesCellular and Molecular Life Sciences, 2019
The insect gustatory system senses taste information from environmental food substrates and processes it to control feeding behaviors. Drosophila melanogaster has been a powerful genetic model for investigating how various chemical cues are detected at ...
Y. Chen, Anupama Dahanukar
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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