Results 91 to 100 of about 617,738 (364)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effects of nighttime odor exposure and delivery methods on subjective sleep quality in healthy adults

Scientific Reports
The role of smell in improving sleep quality is inconclusive. This study aimed to investigate whether the type of odor and the method of application affect sleep quality.
Zetian Li, Jean Christoph Gerami-Manesch, Lisa Marie Hoehnel, Jonathan Warr, Antje Haehner, Thomas Hummel   +5 more
doaj   +1 more source

The coding of valence and identity in the mammalian taste system

Nature, 2018
The ability of the taste system to identify a tastant (what it tastes like) enables animals to recognize and discriminate between the different basic taste qualities1,2.
Li Wang, Li Wang, Sarah Gillis-Smith, Sarah Gillis-Smith, Yueqing Peng, Yueqing Peng, Juen Zhang, Juen Zhang, Xiaoke Chen, Xiaoke Chen, Xiaoke Chen, C. Salzman, N. Ryba, Charles S. Zuker, Charles S. Zuker   +14 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Relationship Between Nasal Trigeminal Receptor Expression and Trigeminal Sensitivity

OTO Open
An intact intranasal trigeminal function is crucial for chemosensory and somatosensory perception, environmental irritation detection, and triggering protective reflexes. Accurately assessing intranasal trigeminal function is thus essential.
Akshita Joshi, Yiling Mai, Susanne Füssel, Thomas Hummel   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review

Frontiers in Genetics, 2019
Background: The rise in nutrition-related morbidity and mortality requires public health intervention programs targeting nutritional behavior. In addition to socio-economical, socio-cultural, psychological determinants, taste is one of the main factors ...
J. Diószegi, E. Llanaj, R. Ádány
semanticscholar   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Granulocyte Colony Stimulating Factor (G‐CSF) and Olfactory Function—A Clinical Pilot Study

Laryngoscope Investigative Otolaryngology
Background Although the olfactory epithelium, including its neuronal cell line, has inherent regenerative potential, therapeutic options remain limited.
C. A. Hintschich, K. Resler, C. Brückner, A. Altundag, K. Trautmann, K. Hölig, F. Kroschinsky, M. Pieniak, T. Hummel   +8 more
doaj   +1 more source