Results 51 to 60 of about 268,731 (242)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Long-term culture and morphological maturation of taste organoids enhance taste discrimination in a biomimetic biosensor

Microsystems & Nanoengineering
Taste is a multifaceted sensory experience that involves various human senses related to food and is a key indicator of food quality. A biomimetic taste-based biosensor, which utilizes taste bud organoids as sensitive elements, is able to simulate the ...
Shuge Liu, Yating Chen, Yuqi Chen, Yuxuan Yuan, Minggao Liu, Zhiyao Wang, Wei Chen, Liping Du, Chunsheng Wu   +8 more
doaj   +1 more source

Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough

ERJ Open Research, 2023
Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because the gustatory nerves innervating taste buds express this same family of ...
Brigit High, Marie E. Jetté, Mei Li, Vijay R. Ramakrishnan, Matthew Clary, Jeremy Prager, Julia Draf, Thomas Hummel, Thomas E. Finger   +8 more
doaj   +1 more source

Synergistic Regulation of Deep‐Cycling‐Induced Zn Pulverization and Resting Galvanic Corrosion in Practical Lean Zinc Anodes

Advanced Science, EarlyView.
Benzotriazole (BTA) regulates Zn reduction kinetics and suppresses galvanic corrosion, simultaneously mitigating Zn pulverization during cycling and self‐corrosion during storage, thereby enabling lean Zn anodes with enhanced cycling stability and extended calendar life.
Jing Xu, Haolin Li, Qiyin Jing, Lingfei Zhao, Elad Ballas, Bing Sun, Doron Aurbach, Guoxiu Wang   +7 more
wiley   +1 more source

LDE225 inhibits new cell entry into the taste bud, resulting in volume reduction by day 10.

, 2023
(A-C) A subset of epidermal basal cells expressing K14CreER:tdTomato were labeled with a single dose of tamoxifen immediately preceding 10 days of treatment with vehicle or LDE225.
David C. Alston (16914231), Aaron W. McGee (15339009), Zachary D. Whiddon (16914225), Robin F. Krimm (16914234), Jaleia B. Marshall (16914228)   +4 more
core   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation

Frontiers in Human Neuroscience, 2021
Sweetness is the preferred taste of humans and many animals, likely because sugars are a primary source of energy. In many mammals, sweet compounds are sensed in the tongue by the gustatory organ, the taste buds.
Elena von Molitor, Katja Riedel, Michael Krohn, Mathias Hafner, Rüdiger Rudolf, Rüdiger Rudolf, Tiziana Cesetti   +6 more
doaj   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Taste bud cells and nerves [PDF]

P(論文)Sectioning of glossopharyngeal nerves which innervate the taste buds in the circumvallate papillae caused apoptosis of taste buds, the numbers decreasing and the taste buds disappearing after 11 days. This indicates that gustatory nerves may release
37271, 内田, 暢彦, 37272, 武田, 正子, 26321, 鈴木, 裕子   +5 more
core   +1 more source

Tribute to Bud Powell (1 of 3)

, 1950
This audio appears to be the soundtrack to a tribute to or a documentary about Bud Powell that may have been put together by Francis Paudras. The audio begins with traffic sounds and the tune "Dance of the Infidels".

core   +1 more source