Results 31 to 40 of about 268,731 (242)

Sox2 is required for development of taste bud sensory cells [PDF]

, 2006
Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae.
Okubo, T., Pevny, L. H., Hogan, B. L.M.
core   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Contribution of Underlying Connective Tissue Cells to Taste Buds in Mouse Tongue and Soft Palate. [PDF]

PLoS ONE, 2016
Taste buds, the sensory organs for taste, have been described as arising solely from the surrounding epithelium, which is in distinction from other sensory receptors that are known to originate from neural precursors, i.e., neural ectoderm that includes ...
Kristin Boggs, Nandakumar Venkatesan, Ingmar Mederacke, Yoshihiro Komatsu, Steve Stice, Robert F Schwabe, Charlotte M Mistretta, Yuji Mishina, Hong-Xiang Liu   +8 more
doaj   +1 more source

Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice

Frontiers in Cellular Neuroscience, 2023
Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama, Ayaka Hirayama, Shusuke Iwata, Asami Oike, Yuko Kawabata, Yuki Nagasato, Shingo Takai, Keisuke Sanematsu, Keisuke Sanematsu, Keisuke Sanematsu, Ichiro Takahashi, Noriatsu Shigemura, Noriatsu Shigemura   +12 more
doaj   +1 more source

A Taste Bud in a Mouse

, 2013
This taste bud was taken from a transgenic mouse in which the marker green fluorescent protein is being driven by the T1R3 promoter; 20%–30% of the cells in the taste bud are expressing T1R3.
Jane Bradbury (2412)
core   +1 more source

METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis

International Journal of Oral Science, 2022
The dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14+ basal cells, discriminates taste compounds and maintains the epithelial barrier.
Qiuchan Xiong, Caojie Liu, Xin Zheng, Xinyi Zhou, Kexin Lei, Xiaohan Zhang, Qian Wang, Weimin Lin, Ruizhan Tong, Ruoshi Xu, Quan Yuan   +10 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

β-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates.

PLoS Genetics, 2015
Continuous taste bud cell renewal is essential to maintain taste function in adults; however, the molecular mechanisms that regulate taste cell turnover are unknown.
Dany Gaillard, Mingang Xu, Fei Liu, Sarah E Millar, Linda A Barlow   +4 more
doaj   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source