Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity [PDF]
Cellular and Molecular Life Sciences, 2022 Taste stem/progenitor cells from posterior mouse tongues have been used to generate taste bud organoids. However, the inaccessible location of taste receptor cells is observed in conventional organoids.
Hyun-Yi Kim, Ki Woo Kim, Seok Jun Moon
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Suspension-cultured taste bud organoids recapitulate in vivo taste buds [PDF]
Organoid, 2023 Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this
Anish Ashok Adpaikar +2 more
doaj +4 more sources
Whole transcriptome profiling of taste bud cells [PDF]
Scientific Reports, 2017 Analysis of single-cell RNA-Seq data can provide insights into the specific functions of individual cell types that compose complex tissues. Here, we examined gene expression in two distinct subpopulations of mouse taste cells: Tas1r3-expressing type II ...
Sunil K. Sukumaran +5 more
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Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.
PLoS Biology, 2023 Taste bud cells are constantly replaced in taste buds as old cells die and new cells migrate into the bud. The perception of taste relies on new taste bud cells integrating with existing neural circuitry, yet how these new cells connect with a taste ...
Zachary D Whiddon +4 more
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Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells [PDF]
BMC Neuroscience, 2010 Background The mammalian taste bud, a complex collection of taste sensory cells, supporting cells, and immature basal cells, is the structural unit for detecting taste stimuli in the oral cavity.
Brand Joseph +4 more
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Voltage-gated sodium channels in taste bud cells [PDF]
BMC Neuroscience, 2009 Background Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes.
Williams Mark E +8 more
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Functional expression of TMEM16A in taste bud cells [PDF]
Journal of Physiology, 2021 Andres Hernandez-Clavijo +2 more
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Maintenance and turnover of Sox2+ adult stem cells in the gustatory epithelium.
PLoS ONE, 2022 Continuous turnover of taste bud cells in the oral cavity underlies the homeostasis of taste tissues. Previous studies have demonstrated that Sox2+ stem cells give rise to all types of epithelial cells including taste bud cells and non-gustatory ...
Makoto Ohmoto +5 more
doaj +1 more source
The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
Scientific Reports, 2021 The characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (
Yuta Yoshida +3 more
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Taste Receptors beyond Taste Buds
International Journal of Molecular Sciences, 2022 Taste receptors are responsible for detecting their ligands not only in taste receptor cells (TRCs) but also in non-gustatory organs. For several decades, many research groups have accumulated evidence for such “ectopic” expression of taste receptors. More recently, some of the physiologic functions (apart from taste) of these ectopic taste receptors ...
Ki, Su Young, Jeong, Yong Taek
openaire +2 more sources