Results 71 to 80 of about 102,975 (341)

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Long-term culture and morphological maturation of taste organoids enhance taste discrimination in a biomimetic biosensor

Microsystems & Nanoengineering
Taste is a multifaceted sensory experience that involves various human senses related to food and is a key indicator of food quality. A biomimetic taste-based biosensor, which utilizes taste bud organoids as sensitive elements, is able to simulate the ...
Shuge Liu, Yating Chen, Yuqi Chen, Yuxuan Yuan, Minggao Liu, Zhiyao Wang, Wei Chen, Liping Du, Chunsheng Wu   +8 more
doaj   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Implications of Notch Signaling in Taste Cell Replacement [PDF]

, 2017
Cyclophosphamide (CYP) was one of the first chemotherapy drugs developed and used to treat several types of cancer, by disrupting proliferative cells. Unfortunately, CYP is unable to differentiate between cancerous cells and healthy cells turning over ...
D\u27Alessandro, Nicholas B
core   +1 more source

Mouse Mandibular Retromolar Taste Buds Associated With a Mucus Salivary Gland [PDF]

, 2021
Quan T Nguyen, Grace E Beck Coburn, Amber Valentino, Bekir Karabucak, Marco Tizzano   +4 more
openalex   +1 more source

XPC Deficiency Activate Cisplatin‐Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1‐Mediated Ubiquitination of the p53 Protein

Advanced Science, EarlyView.
This study reveals that XPC regulates autophagy signaling beyond its noncanonical DNA repair role, uncovering the XPC‐p‐ATM‐KDM4A‐PHRF1 axis as a novel mechanism for autophagy modulation under DNA damage stress. It identifies PHRF1 as a novel p53 ubiquitin ligase.
Baixiong Zhao, Yaqin Huang, Jiazhong Shi, Xiaozhou Zhou, Johan Bourghardt Fagman, Liwei Wang, Sha Liu, Wuxing Wang, Yuting Liu, Zhiwen Chen, Jin Yang   +10 more
wiley   +1 more source

A glucokinase-linked sensor in the taste system contributes to glucose appetite

Molecular Metabolism, 2022
Objectives: Dietary glucose is a robust elicitor of central reward responses and ingestion, but the key peripheral sensors triggering these orexigenic mechanisms are not entirely known.
Sandrine Chometton, A-Hyun Jung, Lilly Mai, Taylor Dal Bon, Alexa Osorio Ramirez, David W. Pittman, Lindsey A. Schier   +6 more
doaj   +1 more source

A taste of the deep-sea: The roles of gustatory and tactile searching behaviour in the grenadier fish Coryphaenoides armatus [PDF]

, 2007
The deep-sea grenadier fishes (Coryphaenoides spp.) are among the dominant predators and scavengers in the ocean basins that cover much of Earth's surface. Baited camera experiments were used to study the behaviour of these fishes.
Alan J. Jamieson, Alexander, Atema, Bailey, Collins, David M. Bailey, Douglas, Drazen, Finger, Finger, Fishelson, Fox, Franz-Odendaal, Hans-Joachim Wagner, Harvey, Hjellvik, Imants G. Priede, Jamieson, Jones, Klages, Kotrschal, Kotrschal, Merrett, Murray F. Ross, Pohlmann, Premke, Priede, Reutter, Ruxton, Tripathi, Valentincic, von der Emde, Wagner, Wagner, Wagner, Warrant, Warrant, Webb, Whitear, Widder, Wilson   +40 more
core   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Lipopolysaccharide-induced inflammation increases nitric oxide production in taste buds [PDF]

, 2022
Zhizhongbin Wu, Yilin Huang, Weiqing Hu, Liyin Ren, Peihua Jiang, Robert F. Margolskee, Hong Wang, Shan Feng   +7 more
openalex   +1 more source