Results 81 to 90 of about 436,774 (328)

The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance [PDF]

Taste sensitivity to PROP varies greatly among individuals and is associated with polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform papilla density on the anterior tongue surface.
Atzori E, Cabras S, Calò C, Melis M, Muroni P, Nieddu M, Padiglia A, Sogos V, Tepper BJ, Tomassini Barbarossa I, Zonza A   +10 more
core   +1 more source

Interleukin-10 Is Produced by a Specific Subset of Taste Receptor Cells and Critical for Maintaining Structural Integrity of Mouse Taste Buds

Journal of Neuroscience, 2014
Although inflammatory responses are a critical component in defense against pathogens, too much inflammation is harmful. Mechanisms have evolved to regulate inflammation, including modulation by the anti-inflammatory cytokine interleukin-10 (IL-10 ...
P. Feng, Jinghua Chai, Minliang Zhou, Nirvine Simon, Liquan Huang, Hong Wang   +5 more
semanticscholar   +1 more source

Suspension-cultured taste bud organoids recapitulate taste buds

Organoid, 2023
Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this study, we focused on identifying the localization of receptors involved during taste bud ...
Anish Ashok Adpaikar, Jong-Min Lee, Han-Sung Jung   +2 more
openaire   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

A2BR adenosine receptor modulates sweet taste in circumvallate taste buds. [PDF]

PLoS ONE, 2012
In response to taste stimulation, taste buds release ATP, which activates ionotropic ATP receptors (P2X2/P2X3) on taste nerves as well as metabotropic (P2Y) purinergic receptors on taste bud cells.
Shinji Kataoka, Arian Baquero, Dan Yang, Nicole Shultz, Aurelie Vandenbeuch, Katya Ravid, Sue C Kinnamon, Thomas E Finger   +7 more
doaj   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Altered peripheral taste function in a mouse model of inflammatory bowel disease

Scientific Reports, 2023
Increased sugar intake and taste dysfunction have been reported in patients with inflammatory bowel disease (IBD), a chronic disorder characterized by diarrhea, pain, weight loss and fatigue.
Guangkuo Dong, Khaylie Boothe, Lianying He, Yang Shi, Lynnette Phillips McCluskey   +4 more
doaj   +1 more source

Investigating age related changes in taste and affects on sensory perceptions of oral nutritional supplements [PDF]

Background: sip feeds are oral nutritional supplements (ONSs) that are commonly prescribed to malnourished patients to improve their nutritional and clinical status.
Arvidson, BAPEN, BAPEN, Bradley, British Standard Method for Sensory Analysis of Food, Chen, Clara Law, De Araujo, De Graaf, Donald Mottram, Elia, Elia, Fukunaga, Gosney, Kremer, Kremer, Lisa Methven, Margot Gosney, Mattes, McWhirter, Millen, Milne, Mojet, Mojet, NICE. National Institute for Health and Clinical Excellence, ONS, Orla Kennedy, Ralph, Sedwards, Stratton, Sugimoto, Wardwell, Wysocki   +32 more
core   +1 more source

How cold is too cold? A theoretical analysis of the optimal trigger for index insurance for frost damage to crops

American Journal of Agricultural Economics, EarlyView.
Abstract Crop insurance is undoubtedly an extremely valuable element in protecting agricultural businesses, but in many cases standard indemnity‐based products have had very low uptake due to high transaction costs elevating premiums to unaffordable levels.
Amogh Prakasha Kumar, Laura Meriluoto, Richard Watt   +2 more
wiley   +1 more source

Mammalian Taste Bud Cells Utilize Extragemmal 5-Hydroxy-L-Tryptophan to Biosynthesize the Neurotransmitter Serotonin

Frontiers in Cellular Neuroscience, 2018
Serotonin or 5-hydroxytryptamine (5-HT) is an important neurotransmitter that is found in mammalian taste buds and can regulate the output of intragemmal signaling networks onto afferent nerve fibers.
Hong-Ru Pan, Miao Tian, Jian-Bo Xue, Song-Min Li, Xiao-Cui Luo, Xiao Huang, Zhen-Huang Chen, Liquan Huang, Liquan Huang   +8 more
doaj   +1 more source