Results 201 to 210 of about 92,910 (287)

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Point of Care Testing, Rapid Next Generation Sequencing and Artificial Intelligence in Pediatric and Neonatal Healthcare: A Narrative Review. [PDF]

Pharmaceuticals (Basel)
Cianflone A, Coppola L, Primo P, Maisto G, Mastrodonato F, Di Palma MA, Parasole R, Omodei D, Mirabelli P.   +8 more
europepmc   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Single procedure tibialis anterior tendon shortening in combination with Achilles tendon lengthening in unilateral cerebral palsy improves swing phase dorsiflexion in gait. [PDF]

J Child Orthop
Widmer M, Staganello M, Sangeux M, Odorizzi M, Brunner R, Viehweger E.   +5 more
europepmc   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Revolutionizing Laboratory Practices: Pioneering Trends in Total Laboratory Automation. [PDF]

Ann Lab Med
Nam Y, Park HD.
europepmc   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Mechanisms underlying local Ca²⁺ signalling differences between right and left atrial myocytes at normal and increased frequencies. [PDF]

J Physiol
Kim JC, Huynh HT, Luong PK, Trinh TN, Wu Y, Grandi E, Woo SH.   +6 more
europepmc   +1 more source

All Solid Lithium Metal‐Polymer Battery End‐of‐Life: an Investigation of Symmetric, Battery, and Bilayer Cells

Advanced Science, EarlyView.
In this study, the evolution of the lithium (Li)/polymer interface is compared in a realistic pouch cell configuration, either in Li/Li symmetric cell or in full Li/LiFePO4${\rm LiFePO}_4$ batteries thanks to X‐ray micro‐tomography. While Li/Li symmetric cells are the reference cell for probing the interface stability, results demonstrated that the end‐
Lucile Magnier, Didier Devaux, Jérôme Adrien, Ce Xiao, Philippe Dumaz, Margaud Lécuyer, Marc Deschamps, Eric Maire, Renaud Bouchet   +8 more
wiley   +1 more source

Ryanodine receptor stabilization therapy suppresses Ca²⁺- based arrhythmias in a novel model of metabolic HFpEF. [PDF]

J Mol Cell Cardiol
Kaplan AD, Boyman L, Ward CW, Lederer WJ, Greiser M.   +4 more
europepmc   +1 more source