Results 1 to 10 of about 358,968 (348)

Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation

Journal of Neuroinflammation, 2023
Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated β-amyloid (Aβ) and hyperphosphorylated tau ...
Yijun Chen, Yang Yu
semanticscholar   +1 more source

Fabrication of self-supporting structures made of washcoat materials (γ-Al2O3-CeO2) by ceramic stereolithography: Towards digital manufacturing of enhanced catalytic converters

Materials & Design, 2021
Despite increasing interest in the use of alternative fuel, conventional diesel or gasoline powered vehicles still dominate road transportation; removal of their emitted pollutants is a challenge to sustainable transportation. The automotive industry has
Setareh Zakeri, Teemu Vastamäki, Mari Honkanen, Matti Järveläinen, Minnamari Vippola, Erkki Levänen   +5 more
doaj   +1 more source

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Nature Network Boston, 2023
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and ...
B. Bellaver, G. Povala, P. Ferreira, J. Ferrari-Souza, D. Leffa, Firoza Z. Lussier, A. Benedet, N. Ashton, G. Triana-Baltzer, H. Kolb, C. Tissot, J. Therriault, S. Servaes, J. Stevenson, N. Rahmouni, O. Lopez, D. Tudorascu, V. Villemagne, M. Ikonomovic, S. Gauthier, E. Zimmer, H. Zetterberg, K. Blennow, H. Aizenstein, W. Klunk, B. Snitz, P. Maki, R. Thurston, A. Cohen, M. Ganguli, T. Karikari, P. Rosa-Neto, T. Pascoal   +32 more
semanticscholar   +1 more source

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

Nature Network Boston, 2023
Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau aggregates, drug development and clinical diagnosis need cost-effective and accessible specific fluid biomarkers ...
Kanta Horie, Gemma Salvadó, Nicolas R. Barthélemy, S. Janelidze, Yan Li, Ying-jie He, B. Saef, Charles Chen, Hong Jiang, O. Strandberg, A. Pichet Binette, S. Palmqvist, C. Sato, P. Sachdev, A. Koyama, B. Gordon, T. Benzinger, D. Holtzman, J. Morris, N. Mattsson-Carlgren, E. Stomrud, R. Ossenkoppele, S. Schindler, O. Hansson, R. Bateman   +24 more
semanticscholar   +1 more source

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies

International Journal of Molecular Sciences, 2022
Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain.
P. Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, J. Culberson, P. Reddy   +5 more
semanticscholar   +1 more source

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures

Nature Network Boston, 2021
A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might provide accurate prediction about the risk of developing Alzheimer’s disease (AD) dementia.
S. Palmqvist, P. Tideman, N. Cullen, H. Zetterberg, K. Blennow, J. Dage, E. Stomrud, S. Janelidze, N. Mattsson-Carlgren, O. Hansson   +9 more
semanticscholar   +1 more source

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease

Brain : a journal of neurology, 2021
Although recent clinical trials targeting amyloid-β in Alzheimer’s disease have shown promising results, there is increasing evidence suggesting that understanding alternative disease pathways that interact with amyloid-β metabolism and amyloid pathology
J. Pereira, S. Janelidze, Ruben Smith, N. Mattsson-Carlgren, S. Palmqvist, C. Teunissen, H. Zetterberg, E. Stomrud, N. Ashton, K. Blennow, O. Hansson   +10 more
semanticscholar   +1 more source

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

International Journal on Biological Sciences, 2021
Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins ...
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li   +7 more
semanticscholar   +1 more source

Cost-effectiveness of diabetic retinopathy screening programs using telemedicine: a systematic review

Cost Effectiveness and Resource Allocation, 2020
Background Diabetic retinopathy (DR) is a significant global public health and economic burden. DR accounts for approximately 15–17% of all cases of total blindness in the USA and Europe.
Daniel Avidor, Anat Loewenstein, Michael Waisbourd, Amir Nutman   +3 more
doaj   +1 more source

Context-aware hand poses classifying on images and video-sequences using a combination of wavelet transforms, PCA and neural networks

EAI Endorsed Transactions on Context-aware Systems and Applications, 2017
In this paper we propose novel context-aware algorithms for hand poses classifying on images and video-sequences. The proposed hand poses classifying on images algorithm based on Viola-Jones method, wavelet transform, PCA and neural networks.
Phan Ngoc Hoang, Bui Thi Thu Trang
doaj   +1 more source