Results 11 to 20 of about 854,024 (332)
Neuroscience, 2023 Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. In addition, the presence of non-aggregated tau protein, which has been recently discovered, is also commented on.
Hernández, Félix +5 more
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Frontiers in Aging Neuroscience, 2016 Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger ...
Jesus Avila +9 more
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Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases [PDF]
Journal of Neurochemistry, 2009 AbstractTau is a neuronal microtubule‐associated protein. Its hyperphosphorylation plays a critical role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated developmentally, but its dynamic regulation and the responsible kinases or phosphatases remain elusive.
Yi Li +11 more
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Cytoskeleton, 2023 AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified
Goedert, Michel +3 more
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Cost Effectiveness and Resource Allocation, 2020 Background Diabetic retinopathy (DR) is a significant global public health and economic burden. DR accounts for approximately 15–17% of all cases of total blindness in the USA and Europe.
Daniel Avidor +3 more
doaj +1 more source
EAI Endorsed Transactions on Context-aware Systems and Applications, 2017 In this paper we propose novel context-aware algorithms for hand poses classifying on images and video-sequences. The proposed hand poses classifying on images algorithm based on Viola-Jones method, wavelet transform, PCA and neural networks.
Phan Ngoc Hoang, Bui Thi Thu Trang
doaj +1 more source
Tau Aggregates and Tau Pathology
Journal of Alzheimer's Disease, 2008 There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron.
Hernández, Félix, Ávila, Jesús
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International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley +1 more source
Lepton and Photon Interactions at High Energies, 1992 16 pages, 8 figures. Invited talk at the XIX International Symposium on Lepton and Photon Interactions at High Energies (Stanford, August 1999)
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Data‐driven performance metrics for neural network learning
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri +2 more
wiley +1 more source