Results 11 to 20 of about 1,021,795 (377)

Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation

Journal of Neuroinflammation, 2023
Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated β-amyloid (Aβ) and hyperphosphorylated tau ...
Yijun Chen, Yang Yu
semanticscholar   +1 more source

Fabrication of self-supporting structures made of washcoat materials (γ-Al2O3-CeO2) by ceramic stereolithography: Towards digital manufacturing of enhanced catalytic converters

Materials & Design, 2021
Despite increasing interest in the use of alternative fuel, conventional diesel or gasoline powered vehicles still dominate road transportation; removal of their emitted pollutants is a challenge to sustainable transportation. The automotive industry has
Setareh Zakeri, Teemu Vastamäki, Mari Honkanen, Matti Järveläinen, Minnamari Vippola, Erkki Levänen   +5 more
doaj   +1 more source

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Nature Network Boston, 2023
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and ...
B. Bellaver, G. Povala, P. Ferreira, J. Ferrari-Souza, D. Leffa, Firoza Z. Lussier, A. Benedet, N. Ashton, G. Triana-Baltzer, H. Kolb, C. Tissot, J. Therriault, S. Servaes, J. Stevenson, N. Rahmouni, O. Lopez, D. Tudorascu, V. Villemagne, M. Ikonomovic, S. Gauthier, E. Zimmer, H. Zetterberg, K. Blennow, H. Aizenstein, W. Klunk, B. Snitz, P. Maki, R. Thurston, A. Cohen, M. Ganguli, T. Karikari, P. Rosa-Neto, T. Pascoal   +32 more
semanticscholar   +1 more source

Tau Aggregation

Neuroscience, 2023
Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. In addition, the presence of non-aggregated tau protein, which has been recently discovered, is also commented on.
Hernández, Félix, Ferrer, Isidro, Pérez, Mar, Zabala Otaño, Juan Carlos, Rio, José Antonio del, Ávila, Jesús   +5 more
openaire   +4 more sources

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

Nature Network Boston, 2023
Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau aggregates, drug development and clinical diagnosis need cost-effective and accessible specific fluid biomarkers ...
Kanta Horie, Gemma Salvadó, Nicolas R. Barthélemy, S. Janelidze, Yan Li, Ying-jie He, B. Saef, Charles Chen, Hong Jiang, O. Strandberg, A. Pichet Binette, S. Palmqvist, C. Sato, P. Sachdev, A. Koyama, B. Gordon, T. Benzinger, D. Holtzman, J. Morris, N. Mattsson-Carlgren, E. Stomrud, R. Ossenkoppele, S. Schindler, O. Hansson, R. Bateman   +24 more
semanticscholar   +1 more source

Tau Structures [PDF]

Frontiers in Aging Neuroscience, 2016
Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger ...
Jesus Avila, Jesus Avila, Juan S. Jimenez, Carmen Laura Sayas, Marta Bolós, Marta Bolós, Juan C. Zabala, Germán Rivas, Felix Hernandez, Felix Hernandez   +9 more
openaire   +5 more sources

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies

International Journal of Molecular Sciences, 2022
Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain.
P. Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, J. Culberson, P. Reddy   +5 more
semanticscholar   +1 more source

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease

Brain : a journal of neurology, 2021
Although recent clinical trials targeting amyloid-β in Alzheimer’s disease have shown promising results, there is increasing evidence suggesting that understanding alternative disease pathways that interact with amyloid-β metabolism and amyloid pathology
J. Pereira, S. Janelidze, Ruben Smith, N. Mattsson-Carlgren, S. Palmqvist, C. Teunissen, H. Zetterberg, E. Stomrud, N. Ashton, K. Blennow, O. Hansson   +10 more
semanticscholar   +1 more source

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures

Nature Network Boston, 2021
A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might provide accurate prediction about the risk of developing Alzheimer’s disease (AD) dementia.
S. Palmqvist, P. Tideman, N. Cullen, H. Zetterberg, K. Blennow, J. Dage, E. Stomrud, S. Janelidze, N. Mattsson-Carlgren, O. Hansson   +9 more
semanticscholar   +1 more source

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

International Journal on Biological Sciences, 2021
Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins ...
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li   +7 more
semanticscholar   +1 more source