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Tau protein and tau aggregation inhibitors
Neuropharmacology, 2010 Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.Bulic, B., Pickhardt, M., Mandelkow, E., Mandelkow, E. +3 moreopenaire +3 more sourcesTau Secretion
2019 The pathological propagation of Tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with Alzheimer's disease (AD) being most prevalent, but including a range of frontotemporal dementias (FTDs). The extracellular Tau is important during the progression of tauopathies, although Tau is mainly expressed ...Zhi, Ruan, Tsuneya, Ikezuopenaire +2 more sourcesTau Fibrillogenesis
2012 The protein tau is the most abundant microtubule associated protein in the central and peripheral nervous system. In the brain, tau plays a role in the assembly and stabilization of microtubules. The function of tau, however, appears to overlap with other microtubule binding proteins.Nitin, Chaudhary, Ramakrishnan, Nagarajopenaire +2 more sourcesCorrelation measurements in Z-]tau(+)tau(-) and the tau-neutrino helicity
1994 Using data collected with the ALEPH detector at LEP correlations between the decay products of the tau(+) and tau- produced in the decay of the Z have been measured. The measurements performed in the decays tau --> pi nu and tau --> p nu place limits on deviations from the Standard Model.D. Buskulic, I. De Bonis, D. Decamp, P. Ghez, C. Goy, J. P. Lees, M. N. Minard, B. Pietrzyk, F. Ariztizabal, P. Comas, J. M. Crespo, M. Delfino, I. Efthymiopoulos, E. Fernandez, M. Fernandez Bosman, V. Gaitan, L.l. Garrido, T. Mattison, A. Pacheco, C. Padilla, A. Pascual, D. Creanza, M. de Palma, A. Farilla, G. Iaselli, G. Maggi, N. Marinelli, S. Natali, S. Nuzzo, A. Ranieri, G. Raso, F. Romano, F. Ruggieri, G. Selvaggi, L. Silvestris, P. Tempesta, G. Zito, Y. Chai, H. Hu, D. Huang, X. Huang, J. Lin, T. Wang, Y. Xie, D. Xu, R. Xu, J. Zhang, L. Zhang, W. Zhao, G. Bonvicini, J. Boudreau, D. Casper, H. Drevermann, R. W. Forty, G. Ganis, C. Gay, M. Girone, R. Hagelberg, J. Harvey, J. Hilgart, R. Jacobsen, B. Jost, J. Knobloch, I. Lehraus, M. Maggi, C. Markou, M. Martinez, P. Mato, H. Meinhard, A. Minten, R. Miquel, H. G. Moser, P. Palazzi, J. R. Pater, J. A. Perlas, P. Perrodo, J. F. Pusztaszeri, F. Ranjard, L. Rolandi, J. Rothberg, T. Ruan, M. Saich, D. Schlatter, M. Schmelling, F. Sefkow, W. Tejessy, I. R. Tomalin, R. Veenhof, H. Wachsmuth, S. Wasserbaech, W. Wiedenmann, T. Wildish, W. Witzeling, J. Wotschack, Z. Ajaltouni, M. Bardadin Otwinowska, A. Barres, C. Boyer, A. Falvard, P. Gay, C. Guicheney, P. Henrard, J. Jousset, B. Michel, J. C. Montret, D. Pallin, P. Perret, F. Podlyski, J. Proriol, F. Saadi, T. Fearnley, J. B. Hansen, J. D. Hansen, J. R. Hansen, P. H. Hansen, R. Møllerud, B. S. Nilsson, A. Kyriakis, E. Simopoulou, I. Siotis, A. Vayaki, K. Zachariadou, J. Badier, A. Blondel, G. Bonneaud, J. C. Brient, P. Bourdon, G. Fouque, S. Orteu, A. Rougé, M. Rumpf, R. Tanaka, M. Verderi, H. Videau, D. J. Candlin, M. I. Parsons, E. Veitch, E. Focardi, L. Moneta, G. Parrini, M. Corden, C. Georgiopoulos, D. E. Jaffe, D. Levinthal, A. Antonelli, R. Baldini, G. Bencivenni, G. Bologna, F. Bossi, P. Campana, G. Capon, F. Cerutti, V. Chiarella, G. Felici, P. Laurelli, G. Mannocchi, F. Murtas, G. P. Murtas, L. Passalacqua, M. Pepe Altarelli, P. Colrain, I. ten Have, J. G. Lynch, W. Maitland, W. T. Morton, C. Raine, P. Reeves, J. M. Scarr, K. Smith, M. G. Smith, A. S. Thompson, R. M. Turnbull, B. Brandl, O. Braun, C. Geweniger, P. Hanke, V. Hepp, E. E. Kluge, Y. Maumary, A. Putzer, B. Rensch, A. Stahl, K. Tittel, M. Wunsch, R. Beuselinck, D. M. Binnie, W. Cameron, M. Cattaneo, D. J. Colling, P. J. Dornan, J. F. Hassard, N. M. Lieske, A. Moutoussi, J. Nash, S. Patton, D. G. Payne, M. J. Phillips, G. San Martin, J. K. Sedgbeer, A. G. Wright, G. Batignani, CIOCCI, MARIA AGNESE, FERRANTE, ISIDORO, FIDECARO, FRANCESCO, F. Forti, MESSINEO, ALBERTO MARIA, G. Rizzo, TONELLI, GUIDO EMILIO, G. Triggiani, F. Ragusa +209 moreopenaire +3 more sourcesDifferent tau epitopes define Aβ42-mediated tau insolubility
Biochemical and Biophysical Research Communications, 2005 Alzheimer's disease (AD) is characterized by extracellular beta-amyloid (Abeta(42))-containing plaques and intracellular neurofibrillary tangles. The latter are composed of hyperphosphorylated filamentous aggregates of the microtubule-associated protein tau.Pennanen, Luis, Gotz, Juergenopenaire +4 more sourcesSearch for CP violation in Z-]tau-tau
1992 Using the 18.8 pb-1 of data accumulated at LEP in 1990 and 1991 with the ALEPH detector, a direct test of neutral current CP-invariance is performed by a search for CP-odd correlations in Z decays to tau pairs where both tau decay modes are identified. No evidence for CP-violation is observed. The weak dipole moment of the tau has been measured to be d(BUSKULIC D, DECAMP D, GOY C, LEES JP, MINARD MN, MOURS B, ALEMANY R, ARIZTIZABAL F, COMAS P, CRESPO JM, DELFINO M, FERNANDEZ E, GAITAN V, GARRIDO L, MATTISON T, PACHECO A, PASCUAL A, CREANZA D, DEPALMA M, FARILLA A, IASELLI G, MAGGI G, MAGGI M, NATALI S, NUZZO S, QUATTROMINI M, RANIERI A, RASO G, ROMANO F, RUGGIERI F, SELVAGGI G, SILVESTRIS L, TEMPESTA P, ZITO G, HU H, HUANG D, HUANG X, LIN J, LOU J, QIAO C, WANG T, XIE Y, XU D, XU R, ZHANG J, ZHAO W, BAUERDICK LAT, BLUCHER E, BONVICINI G, BOSSI F, BOUDREAU J, CASPER D, DREVERMANN H, FORTY RW, GANIS G, GAY C, HAGELBERG R, HARVEY J, HAYWOOD S, HILGART J, JACOBSEN R, JOST B, KNOBLOCH J, LANCON E, LEHRAUS I, LOHSE T, LUSIANI, Alberto, MARTINEZ M, MATO P, MEINHARD H, MINTEN A, MIQUEL R, MOSER HG, PALAZZI P, PERLAS JA, PUSZTASZERI JF, RANJARD F, REDLINGER G, ROLANDI, LUIGI, ROTHBERG J, RUAN T, SAICH M, SCHLATTER D, SCHMELLING M, SEFKOW F, TEJESSY W, WACHSMUTH H, WIEDENMANN W, WILDISH T, WITZELING W, WOTSCHACK J, AJALTOUNI Z, BADAUD F, BARDADINOTWINOWSKA M, BENCHEIKH AM, ELFELLOUS R, FALVARD A, GAY P, GUICHENEY C, HENRARD P, JOUSSET J, MICHEL B, MONTRET JC, PALLIN D, PERRET P, PIETRZYK B, PRORIOL J, PRULHIERE F, STIMPFL G, FEARNLEY T, HANSEN JD, HANSEN JR, HANSEN PH, MOLLERUD R, NILSSON BS, EFTHYMIOPOULOS I, KYRIAKIS A, SIMOPOULOU E, VAYAKI A, ZACHARIADOU K, BADIER J, BLONDEL A, BONNEAUD G, BRIENT JC, FOUQUE G, ORTEU S, ROSOWSKY A, ROUGE A, RUMPF M, TANAKA R, VERDERI M, VIDEAU H, CANDLIN DJ, PARSONS MI, VEITCH E, MONETA L, PARRINI G, CORDEN M, GEORGIOPOULOS C, IKEDA M, LANNUTTI J, LEVINTHAL D, MERMIKIDES M, SAWYER L, WASSERBAECH S, ANTONELLI A, BALDINI R, BENCIVENNI G, BOLOGNA G, CAMPANA P, CAPON G, CERUTTI F, CHIARELLA V, DETTORREPIAZZOLI B, FELICI G, LAURELLI P, MANNOCCHI G, MURTAS F, MURTAS GP, PASSALACQUA L, PEPEALTARELLI M, PICCHI P, ALTOON B, BOYLE O, COLRAIN P, TENHAVE I, LYNCH JG, MAITLAND W, MORTON WT, RAINE C, SCARR JM, SMITH K, THOMPSON AS, TURNBULL RM, BRANDL B, BRAUN O, FISCHER T, GEWENIGER C, HANKE P, HEPP V, KLUGE EE, MAUMARY Y, PUTZER A, RENSCH B, STAHL A, TITTEL K, WUNSCH M, BELK AT, BEUSELINCK R, BINNIE DM, CAMERON W, CATTANEO M, COLLING DJ, DORNAN PJ, DUGEAY S, GREENE AM, HASSARD JF, LIESKE NM, NASH J, PATTON SJ, BATIGNANI G, FORTI F, LIGABUE, FRANCO, TRIGGIANI G, RAGUSA F +204 moreopenaire +4 more sourcesMeasurement of the Decays $\tau^- \to K^*$ $\nu_\tau$ and $\tau^- \to \rho^- \nu_\tau$
1988 Using the ARGUS detector at DORIS II, we have determined the branching ratios for the decays τ−→K*−vτ and τ−→ρ−vτ to be (1.23 ±0.21−0.21+0.11)% and (21.5±0.4±1.9)%, respectively. These results are in agreement with theoretical expectations based on the standard model.Albrecht, H., Bockmann, P., Sefkow, F., Spengler, J., Wurth, R., Yagil, A., Appuhn, R. D., Drescher, A., Hast, C., Kamp, D., Kolanoski, H., Lindner, A., Glaser, R., Mankel, R., Matthiesen, U., Scheck, H., Schweda, G., Spaan, B., Walther, A., Wegener, D., Gabriel, J. C., Ruf, T., Schael, S., Harder, G., Schubert, Klaus R., Stiewe, J., Strahl, K., Waldi, R., Werner, S., Edwards, K. W., Frisken, William R., Kapitza, H., Kutschke, Robert K., MacFarlane, D. B., Kruger, A., McLean, K. W., Nilsson, A. W., Orr, R. S., Parsons, J. A., Patel, P. M., Prentice, J. D., Seidel, S. C., Swain, J. D., Tsipolitis, G., Yoon, T. S., Nippe, A., Ammar, R., Ball, S., Coppage, D., Davis, R., Kanekal, S., Kwak, N., Bostjancic, B., Kernel, G., Krizan, P., Kriznic, E., Schafer, M., Plesko, M., Cronstrom, H. I., Jonsson, L., Babaev, A., Danilov, M., Fominykh, B., Golutvin, A., Gorelov, I., Lyubimov, V., Rostovtsev, A., Schmidt-Parzefall, W., Semenov, A., Semenov, S., Shevchenko, V., Soloshenko, V., Chistilin, V., Tikhomirov, I., Zaitsev, Yu., Childers, R., Darden, C. W., Fernholz, R. C., Schroder, H., ARGUS Collaboration, Schulz, H. D. +80 moreopenaire +1 more source
