Results 1 to 10 of about 243,600 (356)

A Simple Sandwich Electrochemical Immunosensor for Rapid Detection of the Alzheimer’s Disease Biomarker Tau Protein [PDF]

Biosensors
As a typical biomarker of Alzheimer’s disease, rapid and specific detection of tau protein can help improve the early diagnosis and prognosis of the disease.
Mingzhu Yang, Yihong Chen, Hongyu Sun, Dujuan Li, Yanbin Li   +4 more
doaj   +2 more sources

Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions [PDF]

International Journal of Nanomedicine
Pallabi Sil Paul,1 Mallesh Rathnam,1 Aria Khalili,2 Leonardo M Cortez,1 Mahalashmi Srinivasan,3 Emmanuel Planel,4 Jae-Young Cho,2,5 Holger Wille,3 Valerie L Sim,1 Sue-Ann Mok,3 Satyabrata Kar1 1Department of Medicine (Neurology), Centre for Prions and ...
Paul PS, Rathnam M, Khalili A, Cortez LM, Srinivasan M, Planel E, Cho JY, Wille H, Sim VL, Mok SA, Kar S   +10 more
doaj   +2 more sources

Factors of Cell Degeneration or Death caused by Mutant Tau Protein [PDF]

E3S Web of Conferences, 2021
Tau protein is a microtubule associated protein mainly expressed in neurons. Under pathological conditions, Tau protein is abnormally hyperphosphorylated and separated from microtubules.
Mikiko O
doaj   +1 more source

Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein [PDF]

Royal Society Open Science, 2018
We report an ultrasensitive immunoassay for tau protein—a key marker of Alzheimer's disease. This sensing platform relies on graphene oxide (GO) surfaces conjugated with anti-human tau antibody to provide quantitative binding sites for the tau protein ...
Ao Huang, Luning Zhang, Weiwei Li, Zeyu Ma, Shi Shuo, Tianming Yao   +5 more
doaj   +1 more source

The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type

Cells, 2021
Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology.
Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski, Mirosław Jabłoński   +3 more
doaj   +1 more source

Effect of Strain Rate on Single Tau, Dimerized Tau and Tau-Microtubule Interface: A Molecular Dynamics Simulation Study

Biomolecules, 2021
Microtubule-associated protein (MAP) tau is a cross-linking molecule that provides structural stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer’s disease (AD), dementia, and other neurological disorders.
Md Ishak Khan, Kathleen Gilpin, Fuad Hasan, Khandakar Abu Hasan Al Mahmud, Ashfaq Adnan   +4 more
doaj   +1 more source

Nuclear face of Tau: an inside player in neurodegeneration

Acta Neuropathologica Communications, 2023
Tau (Tubulin associated unit) protein is a major hallmark of Alzheimer’s disease (AD) and tauopathies. Tau is predominantly an axonal protein with a crucial role in the stabilization and dynamics of the microtubules. Since the discovery of Tau protein in
Neelam Younas, Tayyaba Saleem, Abrar Younas, Inga Zerr   +3 more
doaj   +1 more source

Behavioral Abnormalities in Knockout and Humanized Tau Mice

Frontiers in Endocrinology, 2020
Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological
Rafaella Araujo Gonçalves, Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E. Fraser, Paul E. Fraser, Fernanda G. De Felice, Fernanda G. De Felice, Fernanda G. De Felice   +7 more
doaj   +1 more source

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Hyperphosphorylation-induced tau oligomers

Frontiers in Neurology, 2013
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the protein and at this level of phosphorylation it is a soluble cytosolic protein.
Khalid eIqbal, CHENG-XIN eGONG, Fei eLiu
doaj   +1 more source