Results 1 to 10 of about 6,693,552 (304)
Autophagy and Tau Protein [PDF]
International Journal of Molecular Sciences, 2021 Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests
T. Hamano +6 more
semanticscholar +3 more sources
Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein [PDF]
Royal Society Open Science, 2018 We report an ultrasensitive immunoassay for tau protein—a key marker of Alzheimer's disease. This sensing platform relies on graphene oxide (GO) surfaces conjugated with anti-human tau antibody to provide quantitative binding sites for the tau protein ...
Ao Huang +5 more
doaj +2 more sources
A Simple Sandwich Electrochemical Immunosensor for Rapid Detection of the Alzheimer’s Disease Biomarker Tau Protein [PDF]
BiosensorsAs a typical biomarker of Alzheimer’s disease, rapid and specific detection of tau protein can help improve the early diagnosis and prognosis of the disease.
Mingzhu Yang +4 more
doaj +2 more sources
Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions [PDF]
International Journal of NanomedicinePallabi Sil Paul,1 Mallesh Rathnam,1 Aria Khalili,2 Leonardo M Cortez,1 Mahalashmi Srinivasan,3 Emmanuel Planel,4 Jae-Young Cho,2,5 Holger Wille,3 Valerie L Sim,1 Sue-Ann Mok,3 Satyabrata Kar1 1Department of Medicine (Neurology), Centre for Prions and ...
Paul PS +10 more
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Factors of Cell Degeneration or Death caused by Mutant Tau Protein [PDF]
E3S Web of Conferences, 2021 Tau protein is a microtubule associated protein mainly expressed in neurons. Under pathological conditions, Tau protein is abnormally hyperphosphorylated and separated from microtubules.
Mikiko O
doaj +1 more source
A current view on Tau protein phosphorylation in Alzheimer's disease.
Current Opinion in Neurobiology, 2021 The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites.
Susanne Wegmann +2 more
semanticscholar +1 more source
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
semanticscholar +1 more source
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
International Journal of Molecular Sciences, 2021 Tau protein plays a critical role in the assembly, stabilization, and modulation of microtubules, which are important for the normal function of neurons and the brain.
J. Šinský +2 more
semanticscholar +1 more source
Cells, 2021 Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology.
Ryszard Pluta +3 more
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Biomolecules, 2021 Microtubule-associated protein (MAP) tau is a cross-linking molecule that provides structural stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer’s disease (AD), dementia, and other neurological disorders.
Md Ishak Khan +4 more
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