Results 1 to 10 of about 232,797 (334)

Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review [PDF]

Molecules
Tau protein is a microtubule-associated protein that is widely distributed in the central nervous system and maintains and regulates neuronal morphology and function.
Jiakai Yang, Weijia Zhi, Lifeng Wang
doaj   +2 more sources

A Simple Sandwich Electrochemical Immunosensor for Rapid Detection of the Alzheimer’s Disease Biomarker Tau Protein [PDF]

Biosensors
As a typical biomarker of Alzheimer’s disease, rapid and specific detection of tau protein can help improve the early diagnosis and prognosis of the disease.
Mingzhu Yang, Yihong Chen, Hongyu Sun, Dujuan Li, Yanbin Li   +4 more
doaj   +2 more sources

Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions [PDF]

International Journal of Nanomedicine
Pallabi Sil Paul,1 Mallesh Rathnam,1 Aria Khalili,2 Leonardo M Cortez,1 Mahalashmi Srinivasan,3 Emmanuel Planel,4 Jae-Young Cho,2,5 Holger Wille,3 Valerie L Sim,1 Sue-Ann Mok,3 Satyabrata Kar1 1Department of Medicine (Neurology), Centre for Prions and ...
Paul PS, Rathnam M, Khalili A, Cortez LM, Srinivasan M, Planel E, Cho JY, Wille H, Sim VL, Mok SA, Kar S   +10 more
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Factors of Cell Degeneration or Death caused by Mutant Tau Protein [PDF]

E3S Web of Conferences, 2021
Tau protein is a microtubule associated protein mainly expressed in neurons. Under pathological conditions, Tau protein is abnormally hyperphosphorylated and separated from microtubules.
Mikiko O
doaj   +1 more source

Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein [PDF]

Royal Society Open Science, 2018
We report an ultrasensitive immunoassay for tau protein—a key marker of Alzheimer's disease. This sensing platform relies on graphene oxide (GO) surfaces conjugated with anti-human tau antibody to provide quantitative binding sites for the tau protein ...
Ao Huang, Luning Zhang, Weiwei Li, Zeyu Ma, Shi Shuo, Tianming Yao   +5 more
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The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type

Cells, 2021
Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology.
Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski, Mirosław Jabłoński   +3 more
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Effect of Strain Rate on Single Tau, Dimerized Tau and Tau-Microtubule Interface: A Molecular Dynamics Simulation Study

Biomolecules, 2021
Microtubule-associated protein (MAP) tau is a cross-linking molecule that provides structural stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer’s disease (AD), dementia, and other neurological disorders.
Md Ishak Khan, Kathleen Gilpin, Fuad Hasan, Khandakar Abu Hasan Al Mahmud, Ashfaq Adnan   +4 more
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Nuclear face of Tau: an inside player in neurodegeneration

Acta Neuropathologica Communications, 2023
Tau (Tubulin associated unit) protein is a major hallmark of Alzheimer’s disease (AD) and tauopathies. Tau is predominantly an axonal protein with a crucial role in the stabilization and dynamics of the microtubules. Since the discovery of Tau protein in
Neelam Younas, Tayyaba Saleem, Abrar Younas, Inga Zerr   +3 more
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Behavioral Abnormalities in Knockout and Humanized Tau Mice

Frontiers in Endocrinology, 2020
Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological
Rafaella Araujo Gonçalves, Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E. Fraser, Paul E. Fraser, Fernanda G. De Felice, Fernanda G. De Felice, Fernanda G. De Felice   +7 more
doaj   +1 more source

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Frontiers in Neurology, 2021
Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better understand ...
Carolina Alquezar, Shruti Arya, Aimee W. Kao   +2 more
doaj   +1 more source