Results 11 to 20 of about 232,797 (334)

Expression of Tau Protein and Tau mRNA in gastric carcinoma

Asian Journal of Medical Sciences, 2015
Aims and Objectives: To provide theoretical basis for the gastric carcinoma pathogenesis and the clinical targeted therapy. Materials and Methods: We detected the expression of Tau protein and Tau mRNA in 60 cases of gastric carcinoma tissues ...
Chun-hui Li
doaj   +3 more sources

Tau binding protein CAPON induces tau aggregation and neurodegeneration [PDF]

Nature Communications, 2019
To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell death
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito   +8 more
doaj   +4 more sources

Tau protein and adult hippocampal neurogenesis [PDF]

Frontiers in Neuroscience, 2012
Tau protein is a microtubule associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions.
Almudena eFuster-Matanzo, Almudena eFuster-Matanzo, María eLlorens-Martín, María eLlorens-Martín, Jerónimo eJurado-Arjona, Jerónimo eJurado-Arjona, Jesus eAvila, Jesus eAvila, Félix eHernández, Félix eHernández   +9 more
doaj   +6 more sources

Autophagy and Tau Protein [PDF]

International Journal of Molecular Sciences, 2021
Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests that autophagy function is disturbed in AD.
Tadanori Hamano, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Shu-Hui Yen, Yasunari Nakamoto   +6 more
openaire   +2 more sources

Tau: A Signaling Hub Protein [PDF]

Frontiers in Molecular Neuroscience, 2021
Over four decades ago,in vitroexperiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents a major disease-driving event induced by pathological ...
Rebecca L. Mueller, Rebecca L. Mueller, Benjamin Combs, Mohammed M. Alhadidy, Mohammed M. Alhadidy, Scott T. Brady, Scott T. Brady, Gerardo A. Morfini, Gerardo A. Morfini, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan   +11 more
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Amyloidogenesis of Tau protein [PDF]

Protein Science, 2017
AbstractThe role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention ...
Bartosz Nizynski, Wojciech Dzwolak, Krzysztof Nieznanski   +2 more
openaire   +3 more sources

TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation [PDF]

BioMed Research International, 2015
Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved.
Chih-Wei Chang, Jung-Chi Liao, T. Tony Yang, Rueyhung Roc Weng, Ching-Te Kuo   +4 more
openaire   +3 more sources

Tau Protein: Function and Pathology [PDF]

International Journal of Alzheimer's Disease, 2012
In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
David Blum, Hanna Rosenmann, Lars M. Ittner, Rakez Kayed   +3 more
openaire   +3 more sources

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Hyperphosphorylation-induced tau oligomers

Frontiers in Neurology, 2013
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the protein and at this level of phosphorylation it is a soluble cytosolic protein.
Khalid eIqbal, CHENG-XIN eGONG, Fei eLiu
doaj   +1 more source