Results 11 to 20 of about 243,600 (356)
Tau binding protein CAPON induces tau aggregation and neurodegeneration [PDF]
Nature Communications, 2019 To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell death
Shoko Hashimoto +8 more
doaj +3 more sources
Tau protein and adult hippocampal neurogenesis [PDF]
Frontiers in Neuroscience, 2012 Tau protein is a microtubule associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions.
Almudena eFuster-Matanzo +9 more
doaj +5 more sources
Autophagy and Tau Protein [PDF]
International Journal of Molecular Sciences, 2021 Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests that autophagy function is disturbed in AD.
Tadanori Hamano +6 more
openaire +2 more sources
TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation [PDF]
BioMed Research International, 2015 Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved.
Liao, Jung-Chi +4 more
openaire +3 more sources
Tau: A Signaling Hub Protein [PDF]
Frontiers in Molecular Neuroscience, 2021 Over four decades ago,in vitroexperiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents a major disease-driving event induced by pathological ...
Rebecca L. Mueller +11 more
openaire +4 more sources
Amyloidogenesis of Tau protein [PDF]
Protein Science, 2017 AbstractThe role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention ...
Bartosz Nizynski +2 more
openaire +2 more sources
Frontiers in Neurology, 2021 Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better understand ...
Carolina Alquezar +2 more
doaj +1 more source
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +6 more sources
Expression of Tau Protein and Tau mRNA in gastric carcinoma
Asian Journal of Medical Sciences, 2015 Aims and Objectives: To provide theoretical basis for the gastric carcinoma pathogenesis and the clinical targeted therapy. Materials and Methods: We detected the expression of Tau protein and Tau mRNA in 60 cases of gastric carcinoma tissues ...
Chun-hui Li
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources