Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. [PDF]
, 2013 While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson's disease (PD), little is known about the mechanism through which human tau can predispose an individual to this ...
Chang, Hui-Yun +6 more
core +2 more sources
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
Cell Reports, 2016 Summary: Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the ...
Tara Vanderweyde +15 more
doaj +1 more source
Bioengineering, 2020 Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug interactions using a ...
Shubha Jain +6 more
doaj +1 more source
The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura +14 more
core +4 more sources
Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation. [PDF]
PLoS ONE, 2008 Tau, an important microtubule associated protein, has been found to bind to DNA, and to be localized in the nuclei of both neurons and some non-neuronal cells.
Yan Wei +7 more
doaj +1 more source
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. [PDF]
, 2012 Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve ...
Arzberger, Thomas +11 more
core +3 more sources
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]
, 2020 Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie +13 more
core +1 more source
Toxic tau: structural origins of tau aggregation in Alzheimer's disease
Neural Regeneration Research, 2020 Alzheimer’s disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.
Abdullah Al Mamun +3 more
doaj +1 more source
NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]
, 2013 Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core +1 more source
Bio-Protocol, 2018 Dysfunction of the microtubule-associated protein Tau (encoded by the MAPT gene) has been implicated in more than twenty neurodegenerative diseases, including Alzheimer’s.
Joseph McInnes +2 more
doaj +1 more source