Results 31 to 40 of about 232,797 (334)
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. [PDF]
, 2012 Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve ...
Arzberger, Thomas +11 more
core +3 more sources
The Neurotoxic Role of Extracellular Tau Protein [PDF]
International Journal of Molecular Sciences, 2018 Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer’s disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients.
Laura de Diego-García +5 more
openaire +7 more sources
NMR Studies of Tau Protein in Tauopathies [PDF]
Frontiers in Molecular Biosciences, 2021 Tauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has ...
Kristine Kitoka +8 more
openaire +5 more sources
Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation. [PDF]
PLoS ONE, 2008 Tau, an important microtubule associated protein, has been found to bind to DNA, and to be localized in the nuclei of both neurons and some non-neuronal cells.
Yan Wei +7 more
doaj +1 more source
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives [PDF]
, 2019 The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies.
Bucchieri, Fabio +6 more
core +1 more source
Toxic tau: structural origins of tau aggregation in Alzheimer's disease
Neural Regeneration Research, 2020 Alzheimer’s disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.
Abdullah Al Mamun +3 more
doaj +1 more source
The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura +14 more
core +4 more sources
The two shapes of the Tau protein [PDF]
eLife, 2018 Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
openaire +3 more sources
Bio-Protocol, 2018 Dysfunction of the microtubule-associated protein Tau (encoded by the MAPT gene) has been implicated in more than twenty neurodegenerative diseases, including Alzheimer’s.
Joseph McInnes +2 more
doaj +1 more source
NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]
, 2013 Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core +1 more source