Results 41 to 50 of about 243,600 (356)

Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration

Neural Regeneration Research, 2016
Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated,
Guang-bin Zha, Mi Shen, Xiao-song Gu, Sheng Yi   +3 more
doaj   +1 more source

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. [PDF]

, 2014
BackgroundAlzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation.
Adame, Anthony, Doppler, Edith, Jech, Marion, Mante, Michael, Masliah, Eliezer, Moessler, Herbert, Novak, Philipp, Patrick, Christina, Rockenstein, Edward, Trejo, Margarita, Ubhi, Kiren   +10 more
core   +2 more sources

Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review

Molecules
Tau protein is a microtubule-associated protein that is widely distributed in the central nervous system and maintains and regulates neuronal morphology and function.
Jiakai Yang, Weijia Zhi, Lifeng Wang
doaj   +1 more source

Pathology of different tau protein species in neurodegenerative diseases: Alzheimer’s disease, corticobasal degeneration, and progressive supranuclear palsy

مجله علمی دانشگاه علوم پزشکی کردستان, 2021
Background and Aim: Tau protein is a microtubule-associated protein that plays a critical role in microtubule dynamics and maintaining the structure of neurons.
Mohammad Majidi, Aref Rajabi, Shamseddin Ahmadi   +2 more
doaj  

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function [PDF]

, 2014
The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of posttranslational modifications, such ...
A Kimchi, B M Kim, C-H Chen, M-H You, S Lee, T H Lee, X Z Zhou, Y Hong, Y Hong   +8 more
core   +1 more source

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. [PDF]

, 2019
Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices (ACC) is observed in ...
Coppola, Giovanni, Cosme, Celica G, Gan, Li, Gaus, Stephanie E, Geschwind, Daniel H, Grinberg, Lea T, Hepker, Mackenzie, Hwang, Ji-Hye Lee, Lin, Li-Chun, Miller, Bruce L, Nana, Alissa L, Rosen, Howard J, Seeley, William W, Spina, Salvatore   +13 more
core   +1 more source

ALZHEIMER'S DISEASE AND TAU PROTEINS

The Lancet, 1986
info:eu-repo/semantics ...
Brion, Jean Pierre, Flament Durand, Jacqueline, Dustin, Pierre   +2 more
openaire   +3 more sources

Tau Protein: Function and Pathology [PDF]

International Journal of Alzheimer's Disease, 2012
In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
Rosenmann, Hanna, Blum, David, Kayed, Rakez, Ittner, Lars M.   +3 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies [PDF]

, 2007
Background: The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases.
Andreasen N, Brit Mollenhauer, Claudia Trenkwalder, Erik Bahn, Fahn S, Goetz CG, Hans A. Kretzschmar, Hoehn MM, Hughes AJ, Hulstaert F, Jens Wiltfang, Joseph J. Locascio, Knopman DS, Markus Otto, McKeith IG, McKhann G, Metz CE, Michael G. Schlossmacher, Mirko Bibl, Mollenhauer B, Oide T, Peter Brechlin, Petra Steinacker, Schlossmacher MG, Sigrid Poser, Takeuchi Y, Wiltfang J, Wodzig KW   +27 more
core   +1 more source