Results 41 to 50 of about 232,797 (334)

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

Molecular Therapy: Nucleic Acids, 2022
Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau.
Amy Easton, Marianne L. Jensen, Congwei Wang, Peter H. Hagedorn, Yuwen Li, Michael Weed, Jere E. Meredith, Valerie Guss, Kelli Jones, Martin Gill, Carol Krause, Jeffrey M. Brown, Lisa Hunihan, Joanne Natale, Alda Fernandes, Yifeng Lu, Joe Polino, Mark Bookbinder, Greg Cadelina, Yulia Benitex, Ramola Sane, John Morrison, Dieter Drexler, Stephen E. Mercer, Charlotte Bon, Nikhil J. Pandya, Ravi Jagasia, Tai-Hsien Ou Yang, Tania Distler, Fiona Grüninger, Michael Meldgaard, Marco Terrigno, John E. Macor, Charles F. Albright, James Loy, Anja M. Hoeg, Richard E. Olson, Angela M. Cacace   +37 more
doaj   +1 more source

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
core   +6 more sources

Expression and Clinical Significance of Cytoskeleton microtubule-associated - Tau in gastric carcinoma

Journal of College of Medical Sciences-Nepal, 2015
Background and Objectives: Microtubules, the main components of spindles in the mitotic phase, can provide the suitable conditions for unlimited proliferation of tumor cells.
Chun-Hui Li, Meiling Hao, Rajina Sahi
doaj   +1 more source

The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro. [PDF]

PLoS ONE, 2014
The brain-enriched microtubule-associated protein tau, a critical regulator of cytoskeletal dynamics, forms insoluble aggregates in a number of neurodegenerative diseases termed tauopathies, including Alzheimer's disease (AD). Hyperphosphorylation of tau
Qian Chen, Zhou Zhou, Lei Zhang, Shangcheng Xu, Chunhai Chen, Zhengping Yu   +5 more
doaj   +1 more source

Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo [PDF]

, 2010
Our ageing society is confronted with a dramatic increase in patients suffering from tauopathies such as Alzheimer's disease, frontotemporal dementia and others.
Haass, Christian, Paquet, Dominik, Schmid, Bettina   +2 more
core   +1 more source

Tau’s Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal

Frontiers in Neuroscience, 2018
Aggregation of the protein tau is a pathological hallmark of Alzheimer’s disease (AD) and related disorders. However, the molecular mechanisms that lead to tau protein aggregation are still unclear.
Irving E. Vega, Irving E. Vega, Irving E. Vega, Alexandra Sutter, Luke Parks, Andrew Umstead, Magdalena I. Ivanova, Magdalena I. Ivanova   +7 more
doaj   +1 more source

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function [PDF]

, 2014
The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of posttranslational modifications, such ...
A Kimchi, B M Kim, C-H Chen, M-H You, S Lee, T H Lee, X Z Zhou, Y Hong, Y Hong   +8 more
core   +1 more source

Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules

Neurology International
The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules.
Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Araki   +4 more
doaj   +1 more source

Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration

Neural Regeneration Research, 2016
Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated,
Guang-bin Zha, Mi Shen, Xiao-song Gu, Sheng Yi   +3 more
doaj   +1 more source

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways [PDF]

, 2018
Post-translational protein modification controls the function of Tau as a scaffold protein linking a variety of molecular partners. This is most studied in the context of microtubules, where Tau regulates their stability as well as the distribution of ...
Boersema, Paul, Cal\uec, Tito, Foglieni, Chiara, Paganetti, Paolo, Papin, St\ue9phanie, Picotti, Paola, Salvad\ue8, Agnese, Sola, Martina, Ulrich, Giorgio   +8 more
core   +2 more sources