Results 91 to 100 of about 5,819,997 (181)

Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’

Molecular Neurodegeneration
Background While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer’s disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant processes, denoted ‘X’
Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L. Benedet, Nicholas J. Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom   +18 more
doaj   +1 more source

Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

Brain Research Bulletin
The negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated species ...
Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Valeria Melis, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel   +9 more
doaj   +1 more source

Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration

Alzheimer’s Research & Therapy, 2023
Background Frontotemporal lobar degeneration (FTLD) is characterized pathologically by neuronal and glial inclusions of hyperphosphorylated tau or by neuronal cytoplasmic inclusions of TDP43.
Claire Bridel, Juami H. M. van Gils, Suzanne S. M. Miedema, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, August B. Smit, Annemieke J. M. Rozemuller, Sanne Abeln, Charlotte E. Teunissen   +8 more
doaj   +1 more source

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. [PDF]

, 2013
While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson's disease (PD), little is known about the mechanism through which human tau can predispose an individual to this ...
Chang, Hui-Yun, Chiang, Ann-Shyn, Chuang, Chia-Lung, Krantz, David E, Lu, Yu-Ning, Wu, Chia-Lin, Wu, Ting-Han   +6 more
core   +2 more sources

Electrochemical modulation of tau protein phosphorylation levels with biomimetic polyaniline membranes

Sensing and Bio-Sensing Research
Alzheimer's disease (AD) is hallmarked by the accumulation of hyperphosphorylated tau proteins, which disrupt microtubule stability and significantly contribute to neurodegeneration and cognitive decline.
Shang-Chi Chien, Chia-Hsuan Chang, Hung-Ju Wang, Chien-Chih Hsu, Yu-Lin Wang, Ching-Cheng Chuang, Jung-Chih Chen   +6 more
doaj   +1 more source

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration

Molecular Neurodegeneration
Background Amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with Alzheimer’s disease (AD).
Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månberg   +10 more
doaj   +1 more source

The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target

Scientifica, 2012
The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases. Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal filaments in a spectrum of ...
Michael S. Wolfe
doaj   +1 more source

Backbone chemical shift assignments of human 14-3-3$\sigma$ [PDF]

, 2019
14-3-3 proteins are a group of seven dimeric adapter proteins that exert their biological function by interacting with hundreds of phosphorylated proteins, thus influencing their sub-cellular localization, activity or stability in the cell.
Boll, Emmanuelle, Cantrelle, François-Xavier, Hanoulle, Xavier, Landrieu, Isabelle, Merzougui, Hamida, Neves, João   +5 more
core   +3 more sources

Sensitivity analysis of a mathematical model of Alzheimer's disease progression unveils important causal pathways

Frontiers in Neuroinformatics
IntroductionMathematical models serve as essential tools to investigate brain aging, the onset of Alzheimer's disease (AD) and its progression. By studying the representation of the complex dynamics of brain aging processes, such as amyloid beta (Aβ ...
Seyedadel Moravveji, Halima Sadia, Halima Sadia, Nicolas Doyon, Nicolas Doyon, Simon Duchesne, Simon Duchesne, Simon Duchesne   +7 more
doaj   +1 more source