Results 91 to 100 of about 5,915,409 (225)

Tubulins in C. elegans [PDF]

open access: yes, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

open access: yes, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Parallel implementation of stochastic simulation for large-scale cellular processes [PDF]

open access: yes, 2005
Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional ...
Burrage, K., Tian, T.
core   +2 more sources

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

open access: yesMolecular Neurodegeneration, 2020
Background Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and ...
Carl Grant Mangleburg   +10 more
doaj   +1 more source

Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds

open access: yesAlzheimer’s Research & Therapy, 2021
Background Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer’s disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate ...
Julia Remnestål   +11 more
doaj   +1 more source

Structural analysis of intrinsically disordered proteins: computer atomistic simulation [PDF]

open access: yes, 2016
Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures.
Battisti, Anna   +2 more
core  

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]

open access: yes, 2019
Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J   +4 more
core   +2 more sources

Targeting tauopathy with engineered tau-degrading intrabodies [PDF]

open access: yes, 2019
BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies.
Gallardo, Gilbert   +7 more
core   +1 more source

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies [PDF]

open access: yes, 2010
Preprin
Harrington, Charles R   +3 more
core   +1 more source

Tau Proteins and Neurofibrillary Degeneration

open access: yesBrain Pathology, 1991
The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule‐associated protein tau forms an important, if not the sole, constituent of the paired helical filament.
M, Goedert   +2 more
openaire   +2 more sources

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