Results 101 to 110 of about 110,474 (301)

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

Brain-selective kinase (BRSK) interactions with tau as a cause of neurodegeneration [PDF]

Tauopathies are a group of neurodegenerative diseases associated with the build-up of intracellular aggregates of the microtubule-associated protein (MAP) tau, called neurofibrillary tangles (NFT).
Cameron, Charles S.
core  

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems

Advanced Materials, EarlyView.
DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther, Eleni Dalaka, Gotthold Fläschner, Manuel Gómez‐González, Ilia Platzman, Sadaf Pashapour, Michelle Emmert, Pere Roca‐Cusachs, Xavier Trepat, Kerstin Göpfrich   +9 more
wiley   +1 more source

Effects of an OX2R agonist on migration and removal of tau from mouse brain

Scientific Reports
Pathological proteins including tau are produced in neurons and released into interstitial fluid (ISF) in a neural activity-dependent manner during wakefulness.
Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimura   +4 more
doaj   +1 more source

Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels

Advanced Materials Interfaces, EarlyView.
Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley   +1 more source

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Nature Communications, 2018
Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki   +8 more
doaj   +1 more source

The regulation of tau-dependent neurodegeneration by Brain Selective/SAD kinases [PDF]

Brain-selective kinases (BRSK1 and BRSK2) are serine/threonine kinase members of the AMPK-related family of protein kinases, the majority of which are regulated by the upstream kinase LKB1 whilst AMPK itself is regulated by CaMKK. The BRSKs are highly
Lyn-Adams, Ceri Louise
core  

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins [PDF]

, 2019
For unknown reasons, humans appear to be particular susceptible to developing tau pathology leading to neurodegeneration. Transgenic mice are still undoubtedly the most popular and extensively used animal models for studying Alzheimer’s disease and other
Félix Hernández, Esther García, Ivanna Ollá (6250814), García, Esther, Isidro Ferrer, Ferrer, Isidro (Ferrer Abizanda), Hernández Pérez, Félix, Sayas, C. Laura, Syas, C. Laura, Mar Pérez, Mar Pérez (6250820), Ivanna Ollá, Medina, Miguel, Miguel Medina, Pérez, Mar, Raquel Cuadros (616144), Jesús Avila (1239), Isidro Ferrer (169684), Ferrer, Isidro, Esther García (6250817), García García-Esquinas, Esther, Hernández, Félix, Avila, Jesús, Jesús Avila, C Laura Sayas, García-García, Esther, Raquel Cuadros, C. Laura Sayas (6250811), Miguel Medina (1369917), Cuadros, Raquel, Félix Hernández (81418), Ollá, Ivanna, Pérez Martínez, María Mar, Sayas, Carmen Laura   +33 more
core   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source