Results 101 to 110 of about 1,790,741 (301)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Brain-selective kinase (BRSK) interactions with tau as a cause of neurodegeneration [PDF]

Tauopathies are a group of neurodegenerative diseases associated with the build-up of intracellular aggregates of the microtubule-associated protein (MAP) tau, called neurofibrillary tangles (NFT).
Cameron, Charles S.
core  

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model.

, 2010
We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner.
Brion, Jean Pierre, Valèrie Suain, Michèle Authelet, Jean-Pierre Brion, Robert De Decker, De Decker, Robert, Kunie Ando, Karelle Leroy, Anna Kabova, Zehra Yilmaz, Suain, Valérie, Ando, Kunie, Yilmaz, Zehra, Leroy, Karelle, Kabova, Anna, Authelet, Michèle, Céline Heraud, Heraud, Céline   +17 more
core   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Data_Sheet_1_Neuronal ER-Signalosome Proteins as Early Biomarkers in Prodromal Alzheimer's Disease Independent of Amyloid-β Production and Tau Phosphorylation.PDF

, 2022
There exists considerable interest to unveil preclinical period and prodromal stages of Alzheimer's disease (AD). The mild cognitive impairment (MCI) is characterized by significant memory and/or other cognitive domains impairments, and is often ...
Raquel Marín (12505675), Mesa, Fátima, Eduardo Torrealba (12505678), Guido Santos (171018), Marín, Raquel, Torrealba, Eduardo, Fátima Mesa-Herrera (12505672), Mario Díaz (415962), Santos, Guido, Díaz, Mario   +9 more
core   +1 more source

Aβ‐ and tau‐associated neuroinflammatory signatures in Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Neuroinflammation is increasingly recognized as a key contributor to Alzheimer's disease (AD) progression, with distinct responses linked to amyloid beta (Aβ) and tau pathology.
Bruna Bellaver, Guilherme Povala, Marco Antônio De Bastiani, Ilaria Pola, Pamela C. L. Ferreira, Guilherme Bauer‐Negrini, João Pedro Ferrari‐Souza, Douglas T. Leffa, Firoza Z. Lussier, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Riddhi Patira, Serge Gauthier, Dana L. Tudorascu, Thomas K. Karikari, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Eduardo R. Zimmer, Andrea L. Benedet, Pedro Rosa‐Neto, Tharick A. Pascoal   +23 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

The regulation of tau-dependent neurodegeneration by Brain Selective/SAD kinases [PDF]

Brain-selective kinases (BRSK1 and BRSK2) are serine/threonine kinase members of the AMPK-related family of protein kinases, the majority of which are regulated by the upstream kinase LKB1 whilst AMPK itself is regulated by CaMKK. The BRSKs are highly
Lyn-Adams, Ceri Louise
core  

Effects of an OX2R agonist on migration and removal of tau from mouse brain

Scientific Reports
Pathological proteins including tau are produced in neurons and released into interstitial fluid (ISF) in a neural activity-dependent manner during wakefulness.
Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimura   +4 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source