Results 121 to 130 of about 110,474 (301)

A Simple Model to Study Tau Pathology

, 2016
Tau proteins play a role in the stabilization of microtubules, but in pathological conditions, tauopathies, tau is modified by phosphorylation and can aggregate into aberrant aggregates. These aggregates could be toxic to cells, and different cell models
Hernández Pérez, Félix, Félix Hernández, Ávila, Jesús, Alexander L. Houck, Jesús Ávila, Houck, Alexander L.   +5 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis

Chinese Journal of Contemporary Neurology and Neurosurgery
PET imaging plays a crucial role in the diagnosis and management of autoimmune encephalitis (AE). By detecting the distribution of radiotracers, PET provides a direct visualization of cerebral metabolic activity, revealing distinct metabolic patterns ...
WANG Ning, SUN Yue-qian, WANG Qun
doaj   +1 more source

Tau as a biomarker of neurodegenerative diseases.

, 2008
International audienceThe microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport.
Caillet-Boudin, Marie-Laure, Vanmechelen, Eugeen, Sablonniere, Bernard, Schraen-Maschke, Susanna, Pasquier, Florence, Deramecourt, Vincent, Bombois, Stephanie, Maurage, Claude-Alain, Sergeant, Nicolas, Buee, Luc, Dhaenens, Claire-Marie   +10 more
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Overexpression of EB proteins facilitates tau secretion.

, 2019
A) Increasing amounts of EB1 protein were expressed in HEK-293-tau3R cells (μg plasmid per well). Increased EB1 expression levels (assessed with an anti-GFP antibody, upper panel) correlate with increased amounts of secreted tau observed in the culture ...
Raquel Cuadros (616144), Ivanna Ollá (6250814), Jesús Avila (1239), C. Laura Sayas (6250811), Miguel Medina (1369917), Mar Pérez (6250820), Félix Hernández (81418), Isidro Ferrer (169684), Esther García (6250817)   +8 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Immunocytochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus.

, 1995
International audienceThe immunocytochemistry of Tau proteins in the cortical pyramidal neurons of the adult microcebes has been studied, using antibodies against human normal and pathological Tau proteins.
Bons, N, Silhol, S, Mestre-Francès, N., Petter, A, Delacourte, A., Jallageas, V   +5 more
core   +2 more sources

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique, Philippe Bertrand, Bégard, Séverine, Luc Buée, André Delacourte, Séverine Bégard, Bertrand, Philippe, Hamdane, Malika, Katharina Schindowski, Bretteville, Alexis, Anne-Véronique Sambo, Schindowski, Katharina, Delacourte, André, Buée, Luc, Malika Hamdane, Alexis Bretteville   +15 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source