Results 91 to 100 of about 1,790,741 (301)
Brain Research BulletinThe negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated species ...
Karima Schwab +9 more
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Integrated analysis of the aging brain transcriptome and proteome in tauopathy
Molecular Neurodegeneration, 2020 Background Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and ...
Carl Grant Mangleburg +10 more
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The two shapes of the Tau protein [PDF]
eLife, 2018 Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
openaire +3 more sources
Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam
Advanced Engineering Materials, EarlyView.Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva +2 more
wiley +1 more source
Advanced Functional Materials, EarlyView.ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti +16 more
wiley +1 more source
, 2004 Solvation energy calculation is one of the main difficulties for the estimation of protein-ligand binding free energy and the correct scoring in docking studies.
Zhou, JJ, Wang, Q, Pei, JF, Lai, LH
core +1 more source
Liquid-liquid phase-separated tau colocalizes with and stabilizes Aβ oligomers
Communications ChemistryProtein aggregation is a hallmark of neurodegenerative diseases, where misfolded proteins accumulate into insoluble deposits. Emerging studies indicate that liquid-liquid phase separation (LLPS) may serve as a transient stage in the transition from ...
Tina Jacob +6 more
doaj +1 more source
Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces
Advanced Functional Materials, EarlyView.Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng +20 more
wiley +1 more source
The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target
Scientifica, 2012 The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases. Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal filaments in a spectrum of ...
Michael S. Wolfe
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Artificial Intelligence Meets Micro/Nanorobotics
Advanced Materials, EarlyView.Artificial intelligence is transforming micro‐ and nanorobots from externally controlled, task‐specific machines into adaptive, autonomous systems. Machine learning, multimodal perception, digital twins, AI‐guided materials and geometry design enhance propulsion, localization, decision‐making, whichaccelerates clinical and environmental applications ...
Fatma M. Yurtsever +6 more
wiley +1 more source