Results 91 to 100 of about 110,474 (301)
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Sensing and Bio-Sensing ResearchAlzheimer's disease (AD) is hallmarked by the accumulation of hyperphosphorylated tau proteins, which disrupt microtubule stability and significantly contribute to neurodegeneration and cognitive decline.
Shang-Chi Chien +6 more
doaj +1 more source
, 2020 Tauopathies are a heterogeneous group of neurodegenerative diseases, characterized by the deposition of pathological tau (p-tau) proteins in distinct brain regions. The hypothesised spread of tau pathology between different brain regions is
Sárkány, Barbara
core
Double‐Interpenetrating Composite Bioink for Multi‐Component 3D Bioprinting and Biofabrication
Advanced Functional Materials, EarlyView.Marine‐polysaccharides‐derived double interpenetrating network hydrogel‐based bioink, combining the attributes of physical and ionic crosslinking, enables room‐temperature bioprinting of mechanically defined structures that can be handled and are cytocompatible.
Fabian Tribukait‐Riemenschneider +1 more
wiley +1 more source
Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model.
, 2010 We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner.
Brion, Jean Pierre +17 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal +7 more
wiley +1 more source
Molecular NeurodegenerationBackground Amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with Alzheimer’s disease (AD).
Sára Mravinacová +10 more
doaj +1 more source
Associations Between APOE Variants, Tau and α-Synuclein
, 2019 Neurodegenerative diseases are characterized by the aggregation and deposition of misfolded proteins in the brain, most prominently amyloid-β (Aβ), tau and α-synuclein (α-syn), and are thus referred to as proteinopathies.
Henrietta M. Nielsen +3 more
core +1 more source
Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing
Advanced Healthcare Materials, EarlyView.We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu +8 more
wiley +1 more source
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]
, 2007 So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Steinacker, Petra +8 more
core +1 more source