Results 121 to 130 of about 5,828,673 (370)

The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target

Scientifica, 2012
The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases. Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal filaments in a spectrum of ...
Michael S. Wolfe
doaj   +1 more source

Targeting tauopathy with engineered tau-degrading intrabodies [PDF]

, 2019
BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies.
Gallardo, Gilbert, Holtzman, David M, Jiang, Hong, Leyns, Cheryl E G, Lin, Kent H, Mann, Carolyn N, Ricardez, Sara M, Wong, Connie H   +7 more
core   +1 more source

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. [PDF]

, 2019
We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset.
A Butler, A Lalazar, A Llado, Aaron P. Schultz, Ana Baena, Arabiye Artola, AS Fleisher, Claudia Marino, D Smedley, Daniel J. Norton, David Aguillon, David Leyton-Cifuentes, DC Aguirre-Acevedo, Dhanesh Amarnani, DM Walsh, DT Chien, E Hudry, EC Mormino, Edmarie Guzmán-Vélez, EH Corder, Enmanuelle Pardilla-Delgado, Eric M. Reiman, Francisco Lopera, Gyungah R. Jun, H Braak, H Braak, Henrik Zetterberg, J Logan, JA Becker, Ji Luo, JI Velez, Jianling Ji, JN Rauch, John B. Miller, Joseph F. Arboleda-Velasquez, Juliana Acosta-Uribe, Justin S. Sanchez, KA Johnson, Kahira L. Saez-Torres, Kaj Blennow, Keith A. Johnson, Kenneth S. Kosik, Kewei Chen, L Wang, L Zhong, Leo A. Kim, Lishuang Shen, M Futamura, M Gisslén, MA Lalli, Marcus Naymik, Margarita Giraldo, Matthew J. Huentelman, Matthew Lalli, Michael O’Hare, Moiz Bootwalla, MR Wardell, N Acosta-Baena, Natalia Chmielewska, O Preische, Pierre N. Tariot, Pradeep Thiyyagura, Rebecca A. Reiman, Reisa A. Sperling, RW Mahley, S Fisher, S Thordardottir, Santiago Delgado-Tirado, Silvia Rios-Romenets, T Hashimoto, T Hashimoto, T Hedden, TM Shoup, WD Knight, Xiaowu Gai, Y Yamauchi, Yakeel T. Quiroz, Yi Su, Yinghua Chen, YT Quiroz   +79 more
core   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’

Molecular Neurodegeneration
Background While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer’s disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant processes, denoted ‘X’
Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L. Benedet, Nicholas J. Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom   +18 more
doaj   +1 more source

Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

Brain Research Bulletin
The negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated species ...
Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Valeria Melis, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel   +9 more
doaj   +1 more source

Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. [PDF]

, 2015
Clinical diagnosis of Alzheimer's disease (AD) relying on symptomatic features has a low specificity, emphasizing the importance of the pragmatic use of neurochemical biomarkers.
Ivitz, Eszter Virág, Janka, Zoltán, Kálmán, János, Oláh, Zita, Pákáski, Magdolna, Sántha, Miklós, Tóth, Erzsébet Melinda, Zvara, Ágnes   +7 more
core   +1 more source

Integrated Metallo‐Dielectric 3D Hotspots From High Refractive Index Nanodiamond‐Plasmonic Gold Cryosoret Nano‐Assemblies for Photonic Crystal Enhanced Fluorescence

Advanced Functional Materials, EarlyView.
This work presents a novel sensing platform using metallo‐dielectric cryosoret nano‐assemblies and lossless photonic crystals to overcome limitations of conventional plasmonic biosensors. The hybrid system enhances both electric and magnetic field interactions, enabling amplified fluorescence, ultralow detection limits, and prism‐free, objective‐free ...
Seemesh Bhaskar, Weinan Liu, Skye Shepherd, Devinda Wijewardena, Joseph Tibbs, Brian T. Cunningham   +5 more
wiley   +1 more source

Electrochemical modulation of tau protein phosphorylation levels with biomimetic polyaniline membranes

Sensing and Bio-Sensing Research
Alzheimer's disease (AD) is hallmarked by the accumulation of hyperphosphorylated tau proteins, which disrupt microtubule stability and significantly contribute to neurodegeneration and cognitive decline.
Shang-Chi Chien, Chia-Hsuan Chang, Hung-Ju Wang, Chien-Chih Hsu, Yu-Lin Wang, Ching-Cheng Chuang, Jung-Chih Chen   +6 more
doaj   +1 more source

Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]

, 2016
BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea, Boxer, Adam, Karydas, Anna, Kågedal, Katarina, Miller, Bruce, Rojas, Julio C, Seeley, William W, Svenningsson, Per, Svensson, Samuel   +8 more
core   +1 more source