Results 151 to 160 of about 5,828,673 (370)

Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. [PDF]

, 2019
Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau dissociates from microtubules and forms neurotoxic extracellular aggregates ...
Barber, Diane L, Charafeddine, Rabab A, Cortopassi, Wilian A, Jacobson, Matthew P, Lak, Parnian, McKenney, Richard J, Tan, Ruensern, Wittmann, Torsten   +7 more
core  

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome

Movement Disorders, 2010
AbstractDifferentiating corticobasal syndrome (CBS) from progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (PD) can be difficult. To investigate the additional value of cerebrospinal fluid (CSF) biomarkers in the diagnostic differentiation of parkinsonism, we analyzed the CSF concentrations of total protein, lactate and brain ...
Aerts, M.B., Esselink, R.A.J., Bloem, B.R., Verbeek, M.M., Verbeek, M.M.   +4 more
openaire   +4 more sources

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

Frontiers in Neuroscience, 2017
The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading aberrant proteins.
Lindsey B. Shelton, John Koren, Laura J. Blair   +2 more
doaj   +1 more source

Ionic Conductive Textiles for Wearable Technology

Advanced Materials, EarlyView.
Recent advances in ionic conductive textiles for wearable technology are summarized, with a focus on soft ionic conductors that exhibit skin‐like flexibility and tissue‐like ion dynamics. Their structures, key characteristics, manufacturing methods, and diverse applications are reviewed.
Lingtao Fang, Yunlu Zhou, Qiyao Huang
wiley   +1 more source

How Does a Delicate Insect Wing Resist Damage? Chitin Orientation Is Adapted to the Mechanical Demands at the Nanoscale

Advanced Materials, EarlyView.
Nanoscale chitin fiber orientations in the insect wing play a critical role in adapting to complex mechanical demands. These findings reveal two distinct and functionally adaptive chitin orientation patterns in the membranes that vary regionally, optimizing mechanical resilience and deformation control.
Chuchu Li, Jiliang Liu, Manfred Burghammer, Chao Wan, Stanislav N. Gorb, Clemens F. Schaber   +5 more
wiley   +1 more source

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.

PLoS ONE, 2011
BackgroundThe simultaneous accumulation of different misfolded proteins in the central nervous system is a common feature in many neurodegenerative diseases.
Nahuai Badiola, Rita Machado de Oliveira, Federico Herrera, Cristina Guardia-Laguarta, Susana A Gonçalves, Marta Pera, Marc Suárez-Calvet, Jordi Clarimon, Tiago Fleming Outeiro, Alberto Lleó   +9 more
doaj   +1 more source

PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells

Advanced Materials, EarlyView.
Detecting proteins secreted by a single cell while retaining its viability remains challenging. A particles‐in‐particle (PiPs) system made by co‐encapsulating barcoded microparticles (BMPs) with a single cell inside an alginate hydrogel particle is introduced.
Félix Lussier, Byeong‐Ui Moon, Mojra Janta‐Polczynski, Yonatan Morocz, Fabian Svahn, Molly Shen, Ljuboje Lukic, Lidija Malic, Teodor Veres, Andy Ng, David Juncker   +10 more
wiley   +1 more source

Mixed Ionic and Electronic Charge Transport in Conductive Protein Fibers Revealed with DC Electrical Measurements

Advanced Materials, EarlyView.
M13 bacteriophage films deposited on micro interdigitated electrodes behave as a Randles simplified equivalent circuit under direct current. We derive contact and film resistance as well as capacitance of films of M13 phages, aromatic curli fibers or pilA‐containing nanowires.
Daniel Modafferi, Xinxin Hao, Kingsley L.‐J. Wong, Juliana Ferraro, Weijia Zhang, Oliver Xie, Noémie‐Manuelle Dorval Courchesne   +6 more
wiley   +1 more source

Comparison of the effects of microtubule-associated protein 2 and tau on the packing density of in vitro assembled microtubules. [PDF]

, 1987
Mark M. Black
openalex   +1 more source