Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer's Disease. [PDF]
Adv Sci (Weinh)Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Böken D +8 more
europepmc +2 more sources
Hydraulic Pressure‐Programmed Molecular Transport in Tough Hydrogels
Advanced Science, EarlyView.Hydraulic pressure is introduced as a programmable parameter for regulating molecular transport in tough hydrogel membranes. Reversing the pressure direction accelerates or slows transport, tuning characteristic transport times over a 65‐fold range while achieving molecular separation and controlled delivery.
Yijie Cheng +7 more
wiley +1 more source
Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments
Advanced Science, EarlyView.Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang +10 more
wiley +1 more source
Plasma Concentrations of Amyloid-β Peptides, BACE-1, and Tau Proteins in Alzheimer's Disease. [PDF]
Turk J Pharm SciYıldırım N +3 more
europepmc +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
Atypical involvement of Alzheimer's tau proteins in diseases beyond tauopathies. [PDF]
Life MedMeng J +5 more
europepmc +1 more source
Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations. [PDF]
Int J Mol Sci, 2021 Muvva C, Murugan NA, Subramanian V.
europepmc +1 more source
Advanced Science, EarlyView.Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva +7 more
wiley +1 more source
Progress in Optical Methods for the Detection of Two Core Blood Biomarkers of Alzheimer's Disease: Amyloid-Beta and Tau Proteins. [PDF]
Biosensors (Basel)Xia N, Gao F, Zheng C.
europepmc +1 more source