Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning
Advanced Science, EarlyView.ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen +6 more
wiley +1 more source
Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors
Advanced Science, EarlyView.This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung +7 more
wiley +1 more source
Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations. [PDF]
Int J Mol Sci, 2021 Muvva C, Murugan NA, Subramanian V.
europepmc +1 more source
The MAP2/Tau family of microtubule-associated proteins
, 2004 Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved ...
Dehmelt, L. +3 more
core
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. [PDF]
Nat Commun, 2020 Vogel JW +8 more
europepmc +1 more source
stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics
Advanced Science, EarlyView.stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang +3 more
wiley +1 more source
Electrochemical Technology for the Detection of Tau Proteins as a Biomarker of Alzheimer's Disease in Blood. [PDF]
Biosensors (Basel)Wang J, Lu X, He Y.
europepmc +1 more source
PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. [PDF]
Int J Nanomedicine, 2020 Gao J +8 more
europepmc +1 more source