Results 151 to 160 of about 1,790,741 (301)

Tau induces inflammasome activation and microgliosis through acetylating NLRP3

Clinical and Translational Medicine
Background Alzheimer's disease (AD) and related Tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule‐associated protein Tau, which is accompanied by neuroinflammation mediated by activated microglia. However,
Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Liu   +23 more
doaj   +1 more source

Interacting Models of Amyloid-β and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer's Disease. [PDF]

J Alzheimers Dis Rep, 2021
Priya K, Siddesha JM, Dharini S, Shashanka KP.   +3 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Additional file 1: of CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau

, 2018
Figure S1. CSF sTREM2 and the relation to age in hip fracture patients. Figure S2. Triplex MSD measurements of CSF Aβ peptides in dementia patients. Table S1. CSF t-tau/Aβ42 and p-tau/Aβ42 ratios and correlations to CSF sTREM2 in the hip fracture cohort.
Kristi Henjum (2795560), Henrik Zetterberg (144718), Kaj Blennow (58615), Leiv Watne (5926901), Lars Nilsson (330562), Else Quist-Paulsen (5926898)   +5 more
core   +1 more source

Multimodal Bioinspired Self‐Healing Composites Enabling Durable and High‐Efficiency Wearable Perovskite Light‐Emitting Diodes

Advanced Science, EarlyView.
Butterfly wing–inspired intrinsically self‐healing polymer interlayers enable flexible perovskite optoelectronics with high luminance, strain‐insensitive stability, and environmental resilience. These hierarchically structured films redistribute mechanical stress, suppress defect formation, and maintain performance under repeated bending, paving the ...
Loganathan Veeramuthu, Yu‐Chen Wang, Chun‐Tse Tsai, Yen‐Lin Tseng, Xuan Ting King, Tzu‐Ming Hsu, Zhen‐Li Yan, Fang‐Cheng Liang, Pei‐Yin Chen, Georgy Dosovitskiy, Yehonadav Bekenstein, Hyunjin Lee, Tao Zhou, Chi‐Ching Kuo   +13 more
wiley   +1 more source

Tau as a biomarker of neurodegenerative diseases.

, 2008
International audienceThe microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport.
Caillet-Boudin, Marie-Laure, Vanmechelen, Eugeen, Sablonniere, Bernard, Schraen-Maschke, Susanna, Pasquier, Florence, Deramecourt, Vincent, Bombois, Stephanie, Maurage, Claude-Alain, Sergeant, Nicolas, Buee, Luc, Dhaenens, Claire-Marie   +10 more
core   +1 more source

Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ_1-42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells. [PDF]

Chem Res Toxicol, 2022
Abascal ML, Sanjuan J, Moyano P, Sola E, Flores A, Garcia JM, Garcia J, Frejo MT, Del Pino J.   +8 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. [PDF]

Nat Commun, 2021
Vogel JW, Iturria-Medina Y, Strandberg OT, Smith R, Levitis E, Evans AC, Hansson O, Alzheimer’s Disease Neuroimaging Initiative, Swedish BioFinder Study.   +8 more
europepmc   +1 more source

14-3-3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity. [PDF]

Adv Sci (Weinh)
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Zhu S, Han X, Zhang H, Ye C, Xia T, Gu X.   +5 more
europepmc   +2 more sources