Results 191 to 200 of about 1,790,741 (301)

Machine‐Learning‐Assisted Impedance Component Analysis Enables Standardizable Surface Protein Analysis of Extracellular Vesicles Using Engineered Nanovesicles

Advanced Science, EarlyView.
This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song, Neethu Ramakrishnan, Sehyeon Kim, Huiseop Lee, Youngeun Kwon, Jinsik Kim   +5 more
wiley   +1 more source

Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins. [PDF]

J Am Chem Soc
Allahyartorkaman M, Chan TH, Chen EH, Ng ST, Chen YA, Wen JK, Ho MR, Yen HY, Kuan YS, Kuo MH, Chen RP.   +10 more
europepmc   +1 more source

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer's Pathogenesis. [PDF]

Molecules, 2020
Penke B, Szűcs M, Bogár F.
europepmc   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

A Tau fehérje fémionkötő helyeit modellező peptidek komplexképző sajátságainak vizsgálata

, 2019
A réz élettani hatása nem elhanyagolható, hiszen fontos nyomelem az élő szervezet számára. Ahhoz, hogy megismerjük, hogy a metalloenzim milyen funkciót tölt be az élő szervezetben és a fémion hogyan befolyásolja a működését, szükséges megvizsgálnunk ...
Antal, Beáta
core  

Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population. [PDF]

Front Aging Neurosci, 2020
Xiao X, Jiao B, Liao X, Zhang W, Yuan Z, Guo L, Wang X, Zhou L, Liu X, Yan X, Tang B, Shen L.   +11 more
europepmc   +1 more source

Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer's Disease Continuum. [PDF]

Int J Mol Sci
Brusini L, Dolci G, Pini L, Cruciani F, Pizzagalli F, Provero P, Menegaz G, Boscolo Galazzo I, Alzheimer’s Disease Neuroimaging Initiative.   +8 more
europepmc   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins. [PDF]

PLoS One
Chen ZJ, Wu CY, Hsiao FY, Ma JC, Lai G, Chang HH, Lin DP.   +6 more
europepmc   +1 more source

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

Advanced Science, EarlyView.
Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li, Yiman Liu, Liya Liang, Rongming Liu   +3 more
wiley   +1 more source