Results 211 to 220 of about 104,850 (261)

Selected Proteins Involved in the Neuropathology of ASD as the Candidates for Fluid Biomarkers. [PDF]

Molecules
Rutkowski P, Romanowicz A, Mroczko J, Gudowska-Sawczuk M, Mroczko B.   +4 more
europepmc   +1 more source

Protein Modifications and Quality Control System: Target for Alzheimer's Disease Therapy. [PDF]

Int J Mol Sci
Sheikh AM, Yano S, Tabassum S, Bhuiya J, Nagai A.   +4 more
europepmc   +1 more source

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Tau protein and tau aggregation inhibitors

Neuropharmacology, 2010
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.
Bulic, B., Pickhardt, M., Mandelkow, E., Mandelkow, E.   +3 more
openaire   +3 more sources

The discovery of tau protein

Cytoskeleton, 2023
AbstractIn January of this year I received an unexpected request from George Bloom to contribute an historical perspective on “the discovery of tau protein,” an event that occurred roughly 50 years ago. My first thought was that it could not have been that long ago, as the memories of what was my first independent scientific discovery are still fresh ...
openaire   +2 more sources

Phosphorylation of tau protein in tau-transfected 3T3 cells

Molecular Brain Research, 1993
The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs
L A, Sygowski, A W, Fieles, M M, Lo, C W, Scott, C B, Caputo   +4 more
openaire   +2 more sources

Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration

Journal of Alzheimer's Disease, 2019
Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from
Yuanting, Ding, Lijuan, Lei, Chencen, Lai, Zhi, Tang   +3 more
openaire   +2 more sources

Tau protein and neurodegeneration

Molecular Neurobiology, 1990
Many of the human neurodegenerative conditions involve a reorganization of the neuronal cytoskeleton. The way in which the cytoskeleton is reorganized may provide a clue to the nature of the insult causing the neurodegeneration. The most common of these conditions is Alzheimer's disease, in which microtubules are lost from neurites that fill up with ...
openaire   +2 more sources

Functions and malfunctions of the tau proteins

Cellular and Molecular Life Sciences, 2002
The tau proteins belong to the family of microtubule-associated proteins. They are mainly expressed in neurons where they play major regulatory roles in the organization and integrity of the cytoskeleton network. Neurofibrillary changes of abnormally hyperphosphorylated tau are a key lesion in Alzheimer's disease and a number of other tauopathies ...
Roland Brandt
exaly   +3 more sources

Tau protein induces bundling of microtubules in vitro: Comparison of different tau isoforms and a tau protein fragment

Journal of Neuroscience Research, 1992
AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
C W, Scott, A B, Klika, M M, Lo, T E, Norris, C B, Caputo   +4 more
openaire   +2 more sources