Results 221 to 230 of about 104,850 (261)

Tau Protein and Frontotemporal Dementias

2021
Filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (FTDs). Mutations in MAPT, the tau gene, cause approximately 5% of cases of FTD. They proved that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.
Michel, Goedert, Maria Grazia, Spillantini, Benjamin, Falcon, Wenjuan, Zhang, Kathy L, Newell, Masato, Hasegawa, Sjors H W, Scheres, Bernardino, Ghetti   +7 more
openaire   +2 more sources

Tau protein

1999
Abstract A synonymous name is MAPT, but it is not commonly used (only in GeneCards and OMIM databases, see below). There are several homologous proteins, recognized by common sequence motifs in the repeat domain (see below).
Peter Friedhoff, Eckhard Mandelkow
openaire   +1 more source

Tau protein and Alzheimer's disease

Neurobiology of Aging, 1994
The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD.
E M, Mandelkow, E, Mandelkow
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Aggregation of tau protein by aluminum

Brain Research, 1993
Aluminum has been detected in Alzheimer neurofibrillary tangles, but the significance of its presence is unknown. The principal component of tangles is the paired helical filament (PHF), comprised of tau protein. We investigated whether aluminum could induce tau protein to form filaments or aggregate.
C W, Scott, A, Fieles, L A, Sygowski, C B, Caputo   +3 more
openaire   +2 more sources

Tau Protein

2017
This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as ...
openaire   +2 more sources

Binding of Hsp90 to Tau Promotes a Conformational Change and Aggregation of Tau Protein

Journal of Alzheimer's Disease, 2009
Tau pathology, associated with Alzheimer's disease, is characterized by the presence of phosphorylated and aggregated tau. Phosphorylation of tau takes place mainly in the vicinity of the tubulin-binding region of the molecule and its self aggregation is also mediated via this tubulin-binding region.
Tortosa, Elena, Santa María, Ismael, Moreno, Francisco J., Lim, Filip, Pérez, Mar, Ávila, Jesús   +5 more
openaire   +3 more sources

Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau

1990
In aged human brain and particularly in Alzheimer’s disease brain, paired helical filaments (PHF’s) accumulate in the neuronal cells. Recently, it was discovered that tau protein is a component of PHF. Tau protein is one of the brain-specific, microtubule-associated proteins (MAP’s) and promotes the formation of microtubules in vitro and in vivo ...
Koichi Ishiguro, Kazuki Sato, Akira Omori, Kayoko Tomizawa, Tsuneko Uchida, Kazutomo Imahori   +5 more
openaire   +1 more source

Tau protein in Alzheimer's disease

Biochemical Society Transactions, 1995
Goedert, M, Jakes, R, Spillantini, MG, Crowther, RA, Cohen, P, Vanmechelen, E, Probst, A, Gotz, J, Burki, K   +8 more
openaire   +8 more sources

Tau protein structure and dynamics

Alzheimer's disease (AD) is the most common type of dementia. It is characterized by chronic memory defects, alterations in behavior, and cognitive decline. AD is histopathologically characterized by two hallmarks: intracellular accumulation of Tau protein as neurofibrillary tangles (NFTs) and extracellular deposition of amyloid beta.
Subashchandrabose, Chinnathambi, Gowshika, Velmurugan, Madhura, Chandrashekar   +2 more
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Tau-Protein

Der Nervenarzt, 1998
Katharina Buch, M. Riemenschneider, P. Bartenstein, F. Willoch, U. Müller, M. Schmolke, T. Nolde, C. Steinmann, W. G. Guder, A. Kurz   +9 more
openaire   +1 more source