Results 251 to 260 of about 176,754 (305)

The One‐Step Synthesis of Biologically Active Isochromans from Lignin‐Derived Aromatic Monomers in Tunable Deep Eutectic Solvents

Chemistry – A European Journal, EarlyView.
A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi, Anastasiia M. Afanasenko, Antonio A. Castillo‐Garcia, Walid A. M. Elgaher, Jörg Haupenthal, Anna K. H. Hirsch, Katalin Barta   +6 more
wiley   +1 more source

Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner. [PDF]

Proc Natl Acad Sci U S A
Mosconi M, Leonardi C, Armour-Garb Z, Rocutto B, Beeg M, Meisl G, Ortigosa-Pascual L, Broggini L, Salmona M, Ricagno S, Knowles TPJ, Diomede L.   +11 more
europepmc   +1 more source

Discovery of cerebrospinal fluid biomarkers for different dementias using mass spectrometry-based proteomics. [PDF]

Alzheimers Dement (Amst)
Stokkel ME, Vermunt L, Knol JC, Chiasserini D, Parnetti L, Piersma SR, Pham TV, de Goeij-de Haas RR, Lemstra AW, Pijnenburg YAL, Visser PJ, Tijms BM, Teunissen CE, Jimenez CR.   +13 more
europepmc   +1 more source

Endothelial adenosine A_2A receptor activation-mediated Tau hyperphosphorylation leads to blood-brain barrier breakdown in a chronic methamphetamine mouse model. [PDF]

Front Med (Lausanne)
Qian Y, Hu M, Xie X, Ren L, Huang X, Hu S.   +5 more
europepmc   +1 more source

Tau conformation, distribution and PET imaging correlations in progressive supranuclear palsy. [PDF]

Transl Neurodegener
Dong C, Ma JH, Qiao HW, Tamagnan GD, Chan P, Liu SY.   +5 more
europepmc   +1 more source

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Tau protein and tau aggregation inhibitors

Neuropharmacology, 2010
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.
Bulic, B., Pickhardt, M., Mandelkow, E., Mandelkow, E.   +3 more
openaire   +3 more sources

Phosphorylation of tau protein in tau-transfected 3T3 cells

Molecular Brain Research, 1993
The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs
L A, Sygowski, A W, Fieles, M M, Lo, C W, Scott, C B, Caputo   +4 more
openaire   +2 more sources

Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration

Journal of Alzheimer's Disease, 2019
Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from
Yuanting, Ding, Lijuan, Lei, Chencen, Lai, Zhi, Tang   +3 more
openaire   +2 more sources