Results 261 to 270 of about 110,474 (301)

The discovery of tau protein

Cytoskeleton, 2023
AbstractIn January of this year I received an unexpected request from George Bloom to contribute an historical perspective on “the discovery of tau protein,” an event that occurred roughly 50 years ago. My first thought was that it could not have been that long ago, as the memories of what was my first independent scientific discovery are still fresh ...
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Phosphorylation of tau protein in tau-transfected 3T3 cells

Molecular Brain Research, 1993
The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs
L A, Sygowski, A W, Fieles, M M, Lo, C W, Scott, C B, Caputo   +4 more
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Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration

Journal of Alzheimer's Disease, 2019
Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from
Yuanting, Ding, Lijuan, Lei, Chencen, Lai, Zhi, Tang   +3 more
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Tau protein and neurodegeneration

Molecular Neurobiology, 1990
Many of the human neurodegenerative conditions involve a reorganization of the neuronal cytoskeleton. The way in which the cytoskeleton is reorganized may provide a clue to the nature of the insult causing the neurodegeneration. The most common of these conditions is Alzheimer's disease, in which microtubules are lost from neurites that fill up with ...
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Tau protein induces bundling of microtubules in vitro: Comparison of different tau isoforms and a tau protein fragment

Journal of Neuroscience Research, 1992
AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
C W, Scott, A B, Klika, M M, Lo, T E, Norris, C B, Caputo   +4 more
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Tau Protein and Frontotemporal Dementias

2021
Filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (FTDs). Mutations in MAPT, the tau gene, cause approximately 5% of cases of FTD. They proved that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.
Michel, Goedert, Maria Grazia, Spillantini, Benjamin, Falcon, Wenjuan, Zhang, Kathy L, Newell, Masato, Hasegawa, Sjors H W, Scheres, Bernardino, Ghetti   +7 more
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Tau protein

1999
Abstract A synonymous name is MAPT, but it is not commonly used (only in GeneCards and OMIM databases, see below). There are several homologous proteins, recognized by common sequence motifs in the repeat domain (see below).
Peter Friedhoff, Eckhard Mandelkow
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Tau protein and Alzheimer's disease

Neurobiology of Aging, 1994
The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD.
E M, Mandelkow, E, Mandelkow
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Aggregation of tau protein by aluminum

Brain Research, 1993
Aluminum has been detected in Alzheimer neurofibrillary tangles, but the significance of its presence is unknown. The principal component of tangles is the paired helical filament (PHF), comprised of tau protein. We investigated whether aluminum could induce tau protein to form filaments or aggregate.
C W, Scott, A, Fieles, L A, Sygowski, C B, Caputo   +3 more
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Inhibitory Effects of Isobavachalcone on Tau Protein Aggregation, Tau Phosphorylation, and Oligomeric Tau-Induced Apoptosis

ACS Chemical Neuroscience, 2020
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases without any effective medicine treatments. The neurofibrillary tangles containing hyperphosphorylated tau protein are one important pathological characteristic. Thus, one practicable strategy for AD drug design is to discover compounds that could inhibit tau protein ...
Shifeng Xiao, Qiuping Wu, Xuanbao Yao, Jiahao Zhang, Weicong Zhong, Junyi Zhao, Qiong Liu, Mohan Zhang   +7 more
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