Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein [PDF]
, 2001 Jochen Eidenmüller +5 more
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Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source
Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer’s Disease and Stimulates Tau Phosphorylation [PDF]
, 2001 Qi Chen +5 more
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Advanced Science, EarlyView.This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley +1 more source
Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders. [PDF]
FEBS Open BioSahara N, Higuchi M.
europepmc +1 more source
Dynamical decoration of stabilized-microtubules by Tau-proteins. [PDF]
Sci Rep, 2019 Hervy J, Bicout DJ.
europepmc +1 more source
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins. [PDF]
Vaccines (Basel), 2020 García-Arriaza J +7 more
europepmc +1 more source
Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP‐CTFs), associated with tau pathology stages, in Alzheimer's disease [PDF]
, 2002 Nicolas Sergeant +5 more
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Enhancing Spatial Transcriptomics via Spatially Constrained Matrix Decomposition with EDGES
Advanced Science, EarlyView.Imaging‐based spatial transcriptomics technologies are currently limited by their restricted gene detection capacity and low measurement accuracy. Moreover, the insufficient integration of spatial context and single‐cell reference data poses a significant challenge for comprehensive data analysis.
Jinyue Zhao +5 more
wiley +1 more source