Results 281 to 290 of about 5,909,902 (374)

Functions and malfunctions of the tau proteins

Cellular and Molecular Life Sciences (CMLS), 2002
Neelam Shahani, R. Brandt
semanticscholar   +1 more source

Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds

Advanced Science, EarlyView.
This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao, Zhijun Yu, Yu Yan, Jiamin Ding, Wangsiyuan Teng, Chenhe Zhou, Minjun Yao, Wenkan Zhang, Shenzhi Zhao, Fangqian Wang, Zhenxuan Shao, Jinfeng Zhou, Xiaoyong Wu, Chengcheng Yu, Liang Chen, Xiaoqiang Jin   +15 more
wiley   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Time-resolved multirotational dynamics of single solution-phase tau proteins reveals details of conformational variation. [PDF]

Phys Chem Chem Phys, 2019
Foote AK, Manger LH, Holden MR, Margittai M, Goldsmith RH.   +4 more
europepmc   +1 more source

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

Advanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source

The Cellular Distribution and Ser262 Phosphorylation of Tau Protein Are Regulated by BDNF In Vitro

, 2014
Qian Chen, Zhou Zhou, Lei Zhang, Shangcheng Xu, Chunhai Chen, Zhengping Yu   +5 more
openalex   +2 more sources

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Hyperphosphorylated Tau Targeting Human Serum Albumin Fusion Protein as Therapeutics for Alzheimer's Diseases

Sookhee Bang, Jeong Kuen Song, Kwan Hee Lee   +2 more
openalex   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

Piezofluorochromism in Aramid Dyads: Pressure‐Triggered Luminescence Enhancement with Predictable Emission Shifts

Advanced Science, EarlyView.
High‐pressure investigations uncover the structural determinants of luminescence intensity and shifts in aramids, establishing intrinsic intramolecular rotation as a reliable predictor of their piezofluorochromic behavior. Leveraging this insight, conjugation modulation is proposed as a precise strategy to tune their piezofluorochromic properties ...
Yayun Wang, Zhe Jia, Yaru Wang, Lin Wei, Zimin Hao, Yanan Wang, Jingwen Guo, Aisen Li, Lei Li, Kai Wang, Qian Li   +10 more
wiley   +1 more source