Results 281 to 290 of about 5,828,673 (370)

Tau Protein in Frontotemporal Dementia Linked to Chromosome 3 (FTD-3) [PDF]

, 2003
Despina Yancopoulou, R. Anthony Crowther, Lisa Chakrabarti, Susanne Gydesen, Jeremy Brown, Maria Grazia Spillantini   +5 more
openalex   +1 more source

A Sensitive Ratiometric Thermometer Constructed by AIEgen‐Based Mixed Lanthanide MOF for Intracellular Temperature Mapping

Advanced Science, EarlyView.
Temperature is a crucial fundamental physical parameter involved in all life activities. An AIEgen‐based mixed lanthanide MOF is synthesized. In the physiological temperature range, this MOF shows superior performance. To achieve the detection of intracellular temperature, a nanoscale mixed LnMOF is synthesized and further modified to enable the visual
Zhijia Li, Jieping Zhang, Zhiyuan Wu, Hang Lei, Yunfang Zhao, Wenqiu Qi, Xue Gao, Feilong Jiang, Yongsheng Liu, Lian Chen, Maochun Hong   +10 more
wiley   +1 more source

960. Examination of the Pathological Mechanism of the Microtubule Associated Protein Tau Using an HSV Amplicon Based Neuronal Gene Delivery System [PDF]

, 2003

openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease [PDF]

, 2004
Takeshi Kawarabayashi, Mikio Shoji, Linda H. Younkin, Wen-Lang Lin, Dennis W. Dickson, Tetsuro Murakami, Etsuro Matsubara, Kōji Abe, Karen H. Ashe, Steven G. Younkin   +9 more
openalex   +1 more source

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, EarlyView.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

Pseudophosphorylation and Glycation of Tau Protein Enhance but Do Not Trigger Fibrillization in Vitro [PDF]

, 2004
Mihaela Necula, Jeff Kuret
openalex   +1 more source

Diagnostic Accuracy of ELISA and xMAP Technology for Analysis of Amyloid β42 and Tau Proteins

, 2007
Thierry S. M. Reijn, M. Rikkert, W. V. Geel, D. D. Jong, M. Verbeek   +4 more
semanticscholar   +1 more source

Spatially Resolved Mapping of Voltage‐Gated Proton Channel Activity Reveals Delayed Proton Transport in Local Microenvironments

Advanced Science, EarlyView.
A revolutionary imaging platform integrating quantitative single‐molecule photobleaching with ratiometric fluorescence probes enables high‐throughput (≈2300 individually resolvable channels) mapping of individual proton channels in a large field (≈3000 µm2), overcoming the spatial and temporal limitations of conventional electrophysiology.
Jiahua Zhuang, Yang Xu, Yuxian Lu, Shiyang Lyu, Jie Tan, Jiandong Feng   +5 more
wiley   +1 more source

Time-resolved multirotational dynamics of single solution-phase tau proteins reveals details of conformational variation. [PDF]

Phys Chem Chem Phys, 2019
Foote AK, Manger LH, Holden MR, Margittai M, Goldsmith RH.   +4 more
europepmc   +1 more source