Results 171 to 180 of about 27,856 (310)

Diagnosis of Alzheimer’s disease and tauopathies on whole slide histopathology images using a weakly supervised deep learning algorithm [PDF]

, 2023
Minji Kim, Hiroaki Sekiya, Nicholas B. Martin, Monica Castanedes‐Casey, Dennis W. Dickson, Tae Hyun Hwang, Shunsuke Koga   +6 more
openalex   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source

Neuroimaging markers and cognition in cognitively unimpaired older Latinos from the Harvard Aging Brain Study

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Research examining Alzheimer's disease (AD) neuroimaging markers of brain pathology and cognition in older Latino adults remains limited. We compared neuroimaging and cognitive profiles between cognitively unimpaired older Latino and non‐Latino adults from the greater Boston area.
Jairo E. Martinez, Kelly A. Lopez, Michael J. Properzi, Dylan Kirn, Clara Vila‐Castelar, Liliana Ramirez‐Gomez, Marta Gonzalez Catalan, Rachel Buckley, Rebecca E. Amariglio, Dorene M. Rentz, Keith Johnson, Reisa A. Sperling, Yakeel T. Quiroz   +12 more
wiley   +1 more source

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear.
Lina Pineda‐Lopez, David Aguillon, Juan Villar‐Vesga, Pablo Valderrama‐Carmona, Alejandro Guerrero, Anil Upreti, Said Arevalo‐Alquichire, Laura Correa, Karin Mendez‐Castellanos, Diana Castaño, Gloria P. Cardona‐Gomez, Geysson J. Fernandez, Leo A. Kim, Joseph F. Arboleda‐Velasquez, Rafael Posada‐Duque   +14 more
wiley   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Editorial: Tau Pathology in Neurological Disorders

Frontiers in Neurology, 2021
Sonia Do Carmo, Maria Grazia Spillantini, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello   +5 more
doaj   +1 more source

Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy

, 2017
Lilah M. Besser, John F. Crary, Charles Mock, Walter A. Kukull   +3 more
openalex   +2 more sources

Significant contralaterality of temporal-predominant neuroastroglial tauopathy and FTLD-TDP type C presenting with the right temporal variant FTD [PDF]

, 2022
Hidetomo Tanaka, Megan A. Hird, David F. Tang‐Wai, Gábor G. Kovács   +3 more
openalex   +1 more source

Synthesis and Evaluation of Radioiodinated [125I]7‐Iodo‐5H‐Pyrido[4,3‐B]Indole ([125I]CTAU) in Postmortem Human Alzheimer's Disease Brain

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 1, January 2026.
[125I]CTAU, a new analog of [18F]T807, was found to be suitable for imaging tau protein in postmortem human Alzheimer's disease brain slices. [125I]CTAU may be among the smaller ring structures that bind to tau protein. ABSTRACT The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and
Chloe C. McNamara, Agnes P. Biju, Emma Lynn M. Hipolito, Ngan T. B. Nguyen, Christopher Liang, Jogeshwar Mukherjee   +5 more
wiley   +1 more source

Longitudinal MRI Characterization of T1 and T2 Relaxation Times in an Amyloid Mouse Model of Alzheimer's Disease at 11.7 T

NMR in Biomedicine, Volume 39, Issue 1, January 2026.
In this study, we systematically characterized the longitudinal evolution of T1 and T2 relaxation times at the early to middle stage of Tg2576 mouse model representing the amyloidosis subtype of Alzheimer’s disease. We found that rates of change in relaxation times within the thalamus, hypothalamus, and piriform cortex may serve as markers for ...
Soven Kumar, Xiuli Yang, Yuguo Li, Adnan Bibic, Zhiliang Wei   +4 more
wiley   +1 more source