Results 181 to 190 of about 27,856 (310)
Hormonal Contraceptives and Depression: A Proteomic Analysis Using Neuronal Models
PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.ABSTRACT Purpose Hormonal contraceptives are linked to a higher prevalence of depressive symptoms. Given their popularity in Western countries, understanding the biochemical effects on neuronal cells is crucial to minimizing mental health risks. Experimental Design Neural progenitor cells were treated with ethinyl estradiol (EE) and levonorgestrel (LNG)
Sam Thilmany +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu +8 more
wiley +1 more source
P3‐463: TRAJECTORY OF NEUROPSYCHOLOGICAL TEST SCORES IN MILD COGNITIVE IMPAIRMENT COMPARING PRIMARY AGE‐RELATED TAUOPATHY VERSUS ALZHEIMER DISEASE [PDF]
, 2019 Merilee Teylan +8 more
openalex +1 more source
Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers
European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.This review outlines positron emission tomography (PET) biomarkers used in Alzheimer's disease (AD) research and clinical settings, targeting both specific (amyloid, tau) and non‐specific (neurodegeneration, synaptic density, neuroinflammation) processes.
Elif Harput +6 more
wiley +1 more source
Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy [PDF]
, 2020 Johanna Jackson +9 more
openalex +1 more source
European Journal of Neurology, Volume 33, Issue 1, January 2026.ABSTRACT Background Hyposmia is present in most patients with Parkinson's disease (PD), whereas olfaction is usually preserved in its diagnostic mimics. To address the limited evidence from smaller studies, we conducted a meta‐analysis on the diagnostic accuracy of olfactory testing in differentiating PD from clinical look‐alikes.
Christoph Theyer +11 more
wiley +1 more source
α
, 2014 Irene López‐González +4 more
openalex +2 more sources
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
IC‐P‐159: Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy [PDF]
, 2015 Ozama Ismail +16 more
openalex +1 more source