Results 111 to 120 of about 63,418 (298)

Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study

, 2000
There is large body of evidences on the role of taurine in the central mechanisms of thermoregulation in mammals, but it is not clear, whether the hypothermic effect of taurine depends on its interaction with GABA receptors or with a specific receptor ...
Sesti C., Machetti F., Valoti M., Frosini M., Sgaragli G., Donati A., Palmi M., Saponara S.   +7 more
core   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress

, 2000
We investigated whether heat-stress induced hyperthermia could enhance release of both endogenous taurine and GABA from nerve cells into the extracellular compartment thus acting like endogenous cryogens.
Sesti C, FROSINI, MARIA, FUSI, FABIO, MANTOVANI, PIERO, VALOTI, MASSIMO, Della Corte L, Bianchi L, PALMI, MITRI, SGARAGLI, GIAN PIETRO   +8 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

The role of taurine in modulating metal accumulation and gene expression under cadmium stress in Glycyrrhiza glabra

BMC Plant Biology
Background Heavy metal pollution, particularly cadmium (Cd), poses a significant threat to the environment, human health and plant growth. Taurine is an amino acid with antioxidant properties.
Erfan Ghozloo, Seyedeh Homeira Soleimani, Fahimeh Arab Bafrani   +2 more
doaj   +1 more source

Effects of dietary taurine supplementation on polyunsaturated fatty acids, cholesterol, and egg quality of egg of hens

Frontiers in Nutrition
ObjectiveThis study aimed to assess the impact of dietary taurine supplementation on egg quality, polyunsaturated fatty acids, and cholesterol contents in egg during the late laying period in hens.MethodsA total of 102 44-week-old Roman pink laying hens ...
Shunyang Wang, Qiqi Zhang, Huimin Lu, Meng Yu, Mahoud M. Alagawany, Cheng Chen, Zhongxin Zhou   +6 more
doaj   +1 more source

Effect of taurine on toxicity of oxidized cholesterol in rats [PDF]

, 2010
[[abstract]]This research was aimed to study the effect of dietary taurine on the toxicity of oxidized cholesterol in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 3 ...
Yeh, YH (Yeh, Yen-Hung); Chen, MH (Chen, Ming-Hsiung); Lee, YT (Lee, Ya-Ting); Hsieh, HS (Hsieh, Hung-Sheng); Hwang, DF (Hwang, Deng-Fwu)
core  

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Dietary Taurine Reduces Zinc-Induced Toxicity in Male Wistar Rats

, 2012
[[abstract]]Taurine is an agent for treating the heavy metal intoxication and presence of metals such as zinc, copper, and iron may have a role in heavy metal toxicity, a study was undertaken to investigate the effect of taurine on the toxicity of zinc ...
Yen-Hung Yeh;Ya-Ting Lee;You-Liang Hsieh;Deng-Fwu Hwang
core  

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source