Results 141 to 150 of about 91,409 (249)

Hypoadrenocorticism‐like syndrome in a cat with Tritrichomonas foetus infection: a case report

Journal of Small Animal Practice, EarlyView.
A reduced sodium: potassium ratio is an uncommon finding in cats, and is typically associated with conditions such as hypoadrenocorticism, severe renal and cardiovascular diseases, cavitary effusion and certain non‐parasitic gastrointestinal diseases.
M. Crisonà, F. Fracassi, A. M. Tardo, S. Okonji, F. Del Baldo   +4 more
wiley   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Root Structural and Metabolic Plasticity Confers Tolerance to Salinity in Wild Barley Species Grown Under Waterlogging

Plant, Cell &Environment, EarlyView.
ABSTRACT Salinity combined with waterlogging is a major abiotic stress that severely limits crop growth and yield. We investigated species‐specific adaptations to salinity under constant waterlogging conditions in the wild halophytic barleys Hordeum marinum and H. glaucum, compared with the cultivated H. vulgare.
Stanislav Isayenkov, Ljudmilla Borisjuk, Simon Mayer, Alexander Hilo, Dominic Knoch, Tobias Meitzel, Bettina Hause, Yudelsy Antonia Tandron Moya, Hardy Rolletschek, Edgar Peiter, Volodymyr Radchuk   +10 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source

Plant‐protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat

Experimental Physiology, EarlyView.
Abstract Exercise in the heat often causes gastrointestinal (GI) disturbances, which can impair performance. Single amino acid supplementation can attenuate gut damage and enhance exercise tolerance; however, the effectiveness of innate amino acid blends from plant‐based proteins remains underexplored.
Robyn Aitkenhead, Mark Waldron, Gillian E. Conway, Katy Horner, Shane M. Heffernan   +4 more
wiley   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Beyond weight loss, cognitive health, and glycemic control: taurine supplementation as a reprogrammer of adipose tissue plasticity, physical performance, metabolic flexibility, neuroinflammaging, and cardiac remodeling in obesity, aging, and diabetes. [PDF]

Front Nutr
Zhang L, Zhang Y, Wang Y.
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source