Results 151 to 160 of about 63,418 (298)

Sulfur-Containing Amino Acid Plasma Concentrations in Pregnancy; Effects of Physical Activity Interventions and Associations with Neonatal Outcomes-The FitMum Randomized Controlled Trial. [PDF]

Nutrients
Jensen IKB, Roland CB, Trammell SAJ, Knudsen SP, Jessen AD, Bendix JM, Molsted S, Grevengoed TJ, Stallknecht BM, Løkkegaard E, Mortensen OH.   +10 more
europepmc   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Inhibition of Striatal miR-141-3p Ameliorates Cognitive Deficits and Neuroinflammation in an ADHD Animal Model. [PDF]

Pharmaceuticals (Basel)
Chang TM, Chiu CC, Chen YC, Wen ZH, Hsu TC, Tzang BS.   +5 more
europepmc   +1 more source

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Dietary taurine supplementation ameliorates growth performance, intestinal health, and environmental stress tolerance in summer-reared <i>Megalobrama amblycephala</i>. [PDF]

Anim Nutr
Chen K, Chen L, He Z, Xie P, Liu H, Gao Z, Wang H.   +6 more
europepmc   +1 more source

Sedentary ageing remodels the structure–function relationships that underlie calcium signalling at super‐resolution scales in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of calcium spark function and ryanodine receptor (RyR) structure within a sedentary model of ageing. Upon sympathetic stimulation from 1 µM isoprenaline a linear response to calcium spark morphology occurred, accompanied by a biphasic progression of RyR remodelling across age.
Miriam E. Hurley, David Conesa, Alan P. Benson, Michael A. Colman   +3 more
wiley   +1 more source

Salivary metabolic profile in patients with oral squamous cell carcinoma and potentially malignant disorders. [PDF]

Clin Oral Investig
Soiniemi L, Hyvärinen E, Mikkonen J, Jäsberg H, Kashyap B, Kullaa A.   +5 more
europepmc   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Insights Into Gut Microbiota and Metabolic Alterations in Type 1 Diabetes Mellitus. [PDF]

Diabetes Metab Res Rev
Fogagnolo C, Ortiz GU, Ramos da Silva AS, Cristini de Freitas E.   +3 more
europepmc   +1 more source

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba, Keiko Kaihara, Hiroki Tanaka, Naoki Nakagawa, Gentaro Iribe   +4 more
wiley   +1 more source