Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden +1 more
wiley +1 more source
Separation of Taurine and Sodium Sulfate from Simulated Mother Liquor by Electrodialysis and Process Optimization. [PDF]
Zhu H, Cao D, Zhao J.
europepmc +1 more source
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque +11 more
wiley +1 more source
ABSTRACT Functional longevity (FL) is a complex trait that integrates many attributes directly contributing to the successful retention and productivity of a cow within the herd. Consequently, improving FL in beef cattle increases herd profitability. This study aimed to estimate the genetic associations between two alternative FL definitions and traits
Dalila Ribeiro dos Santos +7 more
wiley +1 more source
A taurine metabolism-related gene program defines clinical and biological features of neuroblastoma and yields an 8-gene candidate prognostic model. [PDF]
Zhong B +5 more
europepmc +1 more source
Genetic Evaluation for Functional Longevity in Nellore Cattle
ABSTRACT Stayability (STAY) presents limitations in capturing genetic variability among animals with varying calving records up to 76 months of age. Furthermore, because STAY is measured late in life (typically at 6 years of age), it inherently prolongs generation intervals.
Gabriele de Souza Silva Fernandes +7 more
wiley +1 more source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
Microsatellites Versus Genome-Wide SNPs Data for Pedigree Reconstruction in Twin Simmental Crossbred Cattle. [PDF]
Chen X +8 more
europepmc +1 more source
ABSTRACT Soil nutrient transformation capacity is a critical determinant of sustainable productivity in perennial cropping systems; however, the extent to which high‐yielding crops actively regulate rhizosphere microbial assembly to maintain nutrient availability remains poorly understood.
Yanliang Sun +9 more
wiley +1 more source
Should taurine be pursued further as a supportive nutraceutical for Duchenne muscular dystrophy? Gathering evidence in a zebrafish disease model to confirm or refute the benefits - Stage 1 Report. [PDF]
Vanhove L +8 more
europepmc +1 more source

