Results 171 to 180 of about 63,418 (298)

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

open access: yesGlia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden   +1 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

open access: yesImmunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque   +11 more
wiley   +1 more source

Genetic Associations of Functional Longevity With Sexual Precocity and Growth Traits in Nellore Beef Cattle

open access: yesJournal of Animal Breeding and Genetics, Volume 143, Issue 6, Page 821-833, November 2026.
ABSTRACT Functional longevity (FL) is a complex trait that integrates many attributes directly contributing to the successful retention and productivity of a cow within the herd. Consequently, improving FL in beef cattle increases herd profitability. This study aimed to estimate the genetic associations between two alternative FL definitions and traits
Dalila Ribeiro dos Santos   +7 more
wiley   +1 more source

Genetic Evaluation for Functional Longevity in Nellore Cattle

open access: yesJournal of Animal Breeding and Genetics, Volume 143, Issue 6, Page 834-845, November 2026.
ABSTRACT Stayability (STAY) presents limitations in capturing genetic variability among animals with varying calving records up to 76 months of age. Furthermore, because STAY is measured late in life (typically at 6 years of age), it inherently prolongs generation intervals.
Gabriele de Souza Silva Fernandes   +7 more
wiley   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

open access: yesObesity Reviews, Volume 27, Issue 11, November 2026.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani   +8 more
wiley   +1 more source

Rhizosphere Engineering by Root Exudates: High‐Yielding Alfalfa Recruits Functional PGPR to Sustain Soil Nutrient Availability Under Long‐Term Cultivation

open access: yesPlant, Cell &Environment, Volume 49, Issue 11, Page 8763-8778, November 2026.
ABSTRACT Soil nutrient transformation capacity is a critical determinant of sustainable productivity in perennial cropping systems; however, the extent to which high‐yielding crops actively regulate rhizosphere microbial assembly to maintain nutrient availability remains poorly understood.
Yanliang Sun   +9 more
wiley   +1 more source

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