Results 181 to 190 of about 63,418 (298)

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

open access: yesPlant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng   +7 more
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li   +23 more
wiley   +1 more source

Weighted Single‐Step GWAS Reveals Genetic Mechanisms Underlying Pregnancy Loss in Early Nellore Heifers

open access: yesAnimal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Pregnancy loss (PL) affects reproductive efficiency in beef cattle, yet its genetic architecture remains poorly understood in Bos indicus populations. Here, PL was defined as failure from pregnancy diagnosis to calving, capturing a window approximately 60 days after the breeding season.
Flávia C. Bis   +6 more
wiley   +1 more source

Glycyrrhizic Acid Relieves Fatigue Induced by Acute and Chronic Exercise in Mice via Inhibition of the NF‐κB/NLRP3 Signaling Pathway

open access: yesBrain and Behavior, Volume 16, Issue 10, October 2026.
Molecular mechanism diagram of Gly‐A in the treatment of acute and chronic exercise‐fatigue. ABSTRACT Background Glycyrrhizic acid (Gly‐A) exhibits anti‐inflammatory and antioxidant effects in various central nervous system disorders. Acute fatigue and chronic fatigue (CF) are associated with serious physical and psychological effects.
Xin‐ying Cai   +9 more
wiley   +1 more source

Serum Bile Acid Metabolomics‐Based Machine Learning Model for Non‐Invasive Diagnosis of Gastric Cancer

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) has posed a severe threat to human health. Metabolomics analysis has been applied in the context of multiple diseases, offering new perspectives for the development of non‐invasive detections. Objective We aimed to develop a diagnostic model for GC based on a serum bile acid (BA) panel.
Nuo Yao   +10 more
wiley   +1 more source

Multi‐Omics and Computational Pharmacology Approach With Experimental Validation Reveals the Antiproliferative Activity of Sophoricoside Against Pancreatic Cancer

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated pipeline combining network pharmacology, machine learning, and multi‑omics reveals that sophoricoside suppresses pancreatic cancer cell proliferation through PTPN1, a downstream effector. Elevated PTPN1 correlates with poor prognosis and immune infiltration, positioning it as a promising therapeutic node and prognostic biomarker for this ...
Peng Lin, Wei Cheng, Xin Qi, Jing Li
wiley   +1 more source

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