Results 201 to 210 of about 58,419 (296)

Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK‐Beclin1‐Dependent Mitophagy

Aging Cell, Volume 25, Issue 7, July 2026.
Humanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Ha Young Jang, Suyeon Choi, Soo‐Jin Kim, Sooyun Kim, Dong Hyun Jo, Tae Geol Lee, Kyu‐Sang Park, Jeong Hun Kim   +7 more
wiley   +1 more source

Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers. [PDF]

Geohealth
Ting CY, Chen CT, Yen TH, Wei Lee JK, Lee SH, Chang SJ, Hung TH, Liang HJ, Yang HY, Lin CY.   +9 more
europepmc   +1 more source

EGR1 Mediates Ursodeoxycholic Acid‐Promoted Mitophagy to Prevent Postovulatory Aging of Porcine Oocytes

Aging Cell, Volume 25, Issue 7, July 2026.
This study delivers dual key advances: mechanistically, we uncover a novel role of EGR1 as a pivotal transcriptional regulator that bridges upstream gene expression dysregulation to downstream mitophagic decline in oocyte aging; and translationally, we validate the therapeutic potential of the clinical drug UDCA to counteract oocyte aging.
Ying Zhang, Qianru Han, Yongchao Liu, Wei Shen, Shunfeng Cheng, Xiaoya Li   +5 more
wiley   +1 more source

Protective effect of taurine on skin aging caused by deficiency of B cell-specific Moloney MLV insertion site-1. [PDF]

Am J Transl Res
Li J, Huang M, Chen L, Liu Y, Huang J.
europepmc   +1 more source

Variable electrophysiology before and after block of the two delayed rectifier potassium channels in groups of isolated rabbit ventricular cells

British Journal of Pharmacology, Volume 183, Issue 13, Page 3685-3705, July 2026.
Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist, Muhamad Hifzhudin Noor Aziz, Francis L. Burton, Radostin D. Simitev, Rachel C. Myles, Godfrey L. Smith   +5 more
wiley   +1 more source

Based on metabolome and transcriptome analysis, differences in organic acids of 'Korla Xiangli' fruit from different male parent. [PDF]

Food Chem (Oxf)
Ma X, Xue Y, Ye W, Zhao Y, Maimaiti T, Shikui Z, Wang S, Niu Y.   +7 more
europepmc   +1 more source

Genetic Parameters of Methane Emission, Feed Efficiency, Feeding Behaviour, and Growth Traits in Beef Cattle

Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 496-507, July 2026.
ABSTRACT Climate change has intensified the need to reduce greenhouse gas emissions, particularly methane (CH4) from enteric fermentation. Genetic selection has emerged as a promising mitigation strategy; however, studies on Bos taurus indicus, especially Nellore cattle, remain limited.
J. A. Silva, J. P. S. Valente, L. F. M. Mota, G. R. D. Rodrigues, T. L. S. Soares, J. O. S. Marcatto, A. M. Pelaez, F. M. Monteiro, R. C. Canesin, L. G. Albuquerque, M. E. Z. Mercadante   +10 more
wiley   +1 more source

Response to "Before taurine is recommended for stroke-like episodes in m.3243A > G carriers, its efficacy must be demonstrated by appropriate studies". [PDF]

CEN Case Rep
Yoshida R, Mitsuno R, Azegami T, Yamaguchi S, Hayashi K.   +4 more
europepmc   +1 more source

Contribution of Fat Adjustment to Residual Feed Intake Estimation in Beef Cattle

Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 602-612, July 2026.
ABSTRACT Including fat thickness as a covariate in the regression model used to calculate residual feed intake (RFI) could help preserve carcass quality traits, such as marbling, flavour and juiciness, by accounting for variation in fat deposition.
Larissa Bordin Temp, Letícia Pereira, Marcos Jun‐Iti Yokoo, Cintia Righetti Marcondes, Roberto D. Sainz, Fernando Bussiman, Jorge Hidalgo, Daniela Lourenco, Fernando Baldi   +8 more
wiley   +1 more source

Rumen-Protected Taurine Alleviates Heat Stress Injury in Hu Sheep by Regulating Inflammatory Response, Gut Microbiota and Transcriptome. [PDF]

Animals (Basel)
Wei Y, Zhang Y, Liu X, Chen X, Lu G, Wang Y, Hu X, Ouyang K.   +7 more
europepmc   +1 more source