Results 151 to 160 of about 2,931 (217)
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Syntheses and cytotoxicities of the analogues of the taxoid brevifoliol
European Journal of Medicinal Chemistry, 2008Seven novel brevifoliol analogues have been synthesized by coupling brevifoliol and 2-monosubstituted-4-phenyl-1,3-oxazolidine carboxylic acid after removal of the protecting group with acid treatment. Brevifoliol and its synthesized analogues were tested for their cytotoxic activities against four different human cancer cell lines, oral (KB), breast ...
Sunil K, Chattopadhyay +7 more
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Tetrahedron Letters, 1993
Abstract The aldol condensation of the ketone 6 and the aldehyde 7 followed by an annelation-fragmentation afforded the bicyclo[6.4.0]dodecane derivative 3 with the appropriate functionalities for further elaboration.
S. Arseniyadis +6 more
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Abstract The aldol condensation of the ketone 6 and the aldehyde 7 followed by an annelation-fragmentation afforded the bicyclo[6.4.0]dodecane derivative 3 with the appropriate functionalities for further elaboration.
S. Arseniyadis +6 more
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Fluorescent taxoids as probes of the microtubule cytoskeleton
Cell Motility and the Cytoskeleton, 1998Microtubules are specifically and efficiently visualized with the new fluorescent taxoids 7-O-[N-(4'-fluoresceincarbonyl)-L-alanyl]taxol (FLUTAX) and 7-O-[N-(4'-tetramethylrhodaminecarbonyl)-L-alanyl]taxol (ROTAX). Similarly to taxol, FLUTAX and ROTAX are able to drive inactive GDP-liganded tubulin into microtubule assembly.
J A, Evangelio +7 more
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Taxoids and Multidrug Resistance
1995Taxol is now recognized as one of the most interesting and promising new drugs derived from natural products to enter clinical trials for the treatment of cancer in many years. Its importance to the international movement to preserve biodiversity has been profound and far-reaching, as it represents proof of the potential value of natural products, and ...
Robert A. Newman, Dominic Fan
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The synthesis of novel taxoids for oral administration
Bioorganic & Medicinal Chemistry, 2014A group of novel taxoids, with modifications at C-7, C-10, C-3' and C-14 positions of paclitaxel, was synthesized in order to improve their biological profile by decreasing their affinity with P-glycoprotein (P-gp) and increasing cellular permeability.
Yun-rong, Jing +4 more
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Effects of the hydrophobicity of taxoids on their interaction with tubulin
Bioorganic & Medicinal Chemistry, 2000Modifications of the hydrophobic character at the 7 and 10 positions of the taxoids greatly modified the effect of these drugs on the tubulin microtubule system. The presence of an alkyl chain at these positions decreased the activity while their corresponding more polar analogues restored the activity of these molecules.
D, Guénard +5 more
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Taxoids from the needles of the Canadian yew
Phytochemistry, 2000Systematic characterization of the taxoids in the needles of Taxus canadensis led to the discovery of seven taxanes along with three known congeners. Their structures were rigorously established by spectroscopic methods as 15-benzoyl-10-deacetyl-2-debenzoyl-10-dehydro-abeo-baccat in III; 15-benzoyl-2-debenzoyl-7, 9-dideacetyl-abeo-baccatin VI; N-acetyl-
J, Zhang +3 more
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2003
Introduction Taxoids are a family of diterpene alkaloids sharing a tricyclic taxane core (Figure 9.1A). The most well recognized member of the taxoid family is taxol (Figure 9.1B), a minor cytotoxic component isolated from yew bark (Wani et al., 1971).
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Introduction Taxoids are a family of diterpene alkaloids sharing a tricyclic taxane core (Figure 9.1A). The most well recognized member of the taxoid family is taxol (Figure 9.1B), a minor cytotoxic component isolated from yew bark (Wani et al., 1971).
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Immunoassay for the detection of taxoids
1998info:eu-repo/semantics ...
El Jaziri, Mondher +3 more
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