Results 131 to 140 of about 2,931 (217)

The Cardio-Renal-Hepatic Axis in MASLD. Role of BDNF, NGF, and Metabolic Cross-Talk. [PDF]

Curr Hypertens Rep
Taylor LC, Adenawoola MI, Wingfield CB, Nadolski MK, Stec DE.   +4 more
europepmc   +1 more source

Plants against cancer: towards green Taxol production through pathway discovery and metabolic engineering. [PDF]

aBIOTECH
Zerbe P.
europepmc   +1 more source

A Taxoid From Needles of Himalayan Taxus baccata

Phytochemistry, 1995
13-Acetyl-13-decinnamoyltaxchinin B, a taxoid having a rearranged 11(15 → 1)abeo-taxane skeleton, has been isolated from the needles of the Himalayan yew, Taxus baccata. The compound has not previously been encountered in nature.
K V N S Srinivas, J S Yadav
exaly   +2 more sources

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Taxoid Metabolism: Taxoid 14β-Hydroxylase Is a Cytochrome P450-Dependent Monooxygenase

Archives of Biochemistry and Biophysics, 2003
The production of the anticancer drug Taxol in Taxus (yew) cell cultures is often accompanied by the formation of side-route polyoxygenated taxoid metabolites bearing a 14beta-hydroxyl group. The recent acquisition of several new semisynthetic taxoid intermediates enabled the screening of a family of Taxus cytochrome P450 cDNA clones for the 14beta ...
Robert M Williams, Stefan Jennewein, Rodney Croteau   +2 more
exaly   +3 more sources

Nanoemulsion Formulation of a Novel Taxoid DHA-SBT-1214 Inhibits Prostate Cancer Stem Cell-Induced Tumor Growth

Cancer Letters, 2017
The main aim of this study was to evaluate the therapeutic efficacy of an oil-in-water nanoemulsion formulation encapsulating DHA-SBT-1214, a novel omega-3 fatty acid conjugated taxoid prodrug, against prostate cancer stem cells. Nanoemulsions of DHA-SBT-
Mansoor M. Amiji, Iwao Ojima, Rana El Sadda   +2 more
exaly   +2 more sources

Strategic Incorporation of Fluorine Into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies

Journal of Fluorine Chemistry, 2017
This account exemplifies our recent progress on the strategic incorporation of fluorine and organofluorine groups to taxoid anticancer agents and their tumor-targeted drug delivery systems (TTDDSs) for medicinal chemistry and chemical biology studies ...
Iwao Ojima
exaly   +2 more sources

In Vitro Enzymatic Synthesis of Baccatin III With Novel and Cheap Acetyl Donors by the Recombinant Taxoid 10β-O-Acetyl Transferase

Biocatalysis and Biotransformation, 2019
Despite the importance of baccatin III as a precursor to paclitaxel, a widely used chemotherapeutic agent, efficient enzymatic synthesis methods are lacking.
Jun-Fang Lin, Liqiong Guo, Tao Wei
exaly   +2 more sources

Taxol Biosynthesis: Identification and Characterization of Two Acetyl CoA:Taxoid-O-Acetyl Transferases That Divert Pathway Flux Away From Taxol Production

Archives of Biochemistry and Biophysics, 2009
Two cDNAs encoding taxoid-O-acetyl transferases (TAX 9 and TAX 14) were obtained from a previously isolated family of Taxus acyl/aroyl transferase cDNA clones.
Daniela Hampel, Rodney B Croteau
exaly   +2 more sources

Molecular Cloning and Characterization of a Cytochrome P450 Taxoid 9á-Hydroxylase in Ginkgo biloba Cells

Biochemical and Biophysical Research Communications, 2014
Jianqiang Wu, Iain W Wilson, Deyou Qiu
exaly   +2 more sources