Results 141 to 150 of about 3,991 (207)

Risk Prediction Model for Taxane-Induced Peripheral Neuropathy in Early-Stage Cancer.

JAMA Netw Open
Trivedi MS, Unger JM, Henry NL, Darke AK, Hertz DL, Brannagan TH, Reyes SJ, Schneider BP, Irvin WJ, Hathaway AR, Vander Woude AC, Gudena VK, Cabrera-Galeana P, Orsted M, LeBlanc M, Fisch MJ, Hershman DL.   +16 more
europepmc   +1 more source

Syntheses and cytotoxicities of the analogues of the taxoid brevifoliol

European Journal of Medicinal Chemistry, 2008
Seven novel brevifoliol analogues have been synthesized by coupling brevifoliol and 2-monosubstituted-4-phenyl-1,3-oxazolidine carboxylic acid after removal of the protecting group with acid treatment. Brevifoliol and its synthesized analogues were tested for their cytotoxic activities against four different human cancer cell lines, oral (KB), breast ...
Sunil K, Chattopadhyay, Sarita, Tripathi, Mahendra P, Darokar, Uzma, Faridi, Brijesh, Sisodia, Shubhra, Negi, J, Kotesh Kumar, Suman P S, Khanuja   +7 more
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Taxoids from the needles of the Canadian yew

Phytochemistry, 2000
Systematic characterization of the taxoids in the needles of Taxus canadensis led to the discovery of seven taxanes along with three known congeners. Their structures were rigorously established by spectroscopic methods as 15-benzoyl-10-deacetyl-2-debenzoyl-10-dehydro-abeo-baccat in III; 15-benzoyl-2-debenzoyl-7, 9-dideacetyl-abeo-baccatin VI; N-acetyl-
Orval Mamer, Françoise Sauriol, Lolita O Zamir   +2 more
exaly   +3 more sources

The taxoids: paclitaxel and docetaxel

Lancet, The, 1994
K Gelmon
exaly   +3 more sources

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J

Bioorganic and Medicinal Chemistry Letters, 2007
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R.
Daniele Castagnolo, Maurizio Botta, Ezio Bombardelli   +2 more
exaly   +2 more sources

A new carvone based construction of the ring-A of taxoids

Tetrahedron Letters, 1999
A synthesis of the fully functionalized A-ring of taxoids from the commercially available monoterpenic chiron R-carvone is outlined. In this approach, regio- and stereoselective restructuring of alkyl substituents and functionalities is effected on the ...
Shital Kumar Chattopadhyay, Goverdhan Mehta   +1 more
exaly   +3 more sources

The Taxoids

Drugs, 1998
Paclitaxel and docetaxel are 2 compounds from the new taxoid class of anti-cancer agents. Both drugs are very similar in preclinical activity, mechanism of action and spectrum of clinical activity. Some subtle differences in the intracellular retention of docetaxel may account for its lack of schedule-related myelosuppression and greater potency, and ...
Eisenhauer, Elizabeth A., Vermorken, Jan B.   +1 more
openaire   +3 more sources

Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase

Archives of Biochemistry and Biophysics, 2003
The production of the anticancer drug Taxol in Taxus (yew) cell cultures is often accompanied by the formation of side-route polyoxygenated taxoid metabolites bearing a 14beta-hydroxyl group. The recent acquisition of several new semisynthetic taxoid intermediates enabled the screening of a family of Taxus cytochrome P450 cDNA clones for the 14beta ...
Stefan, Jennewein, Christopher D, Rithner, Robert M, Williams, Rodney, Croteau   +3 more
openaire   +2 more sources