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The synthesis of novel taxoids for oral administration
Bioorganic & Medicinal Chemistry, 2014A group of novel taxoids, with modifications at C-7, C-10, C-3' and C-14 positions of paclitaxel, was synthesized in order to improve their biological profile by decreasing their affinity with P-glycoprotein (P-gp) and increasing cellular permeability.
Yun-rong, Jing +4 more
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Fluorescent taxoids as probes of the microtubule cytoskeleton
Cell Motility and the Cytoskeleton, 1998Microtubules are specifically and efficiently visualized with the new fluorescent taxoids 7-O-[N-(4'-fluoresceincarbonyl)-L-alanyl]taxol (FLUTAX) and 7-O-[N-(4'-tetramethylrhodaminecarbonyl)-L-alanyl]taxol (ROTAX). Similarly to taxol, FLUTAX and ROTAX are able to drive inactive GDP-liganded tubulin into microtubule assembly.
J A, Evangelio +7 more
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Taxoids and Multidrug Resistance
1995Taxol is now recognized as one of the most interesting and promising new drugs derived from natural products to enter clinical trials for the treatment of cancer in many years. Its importance to the international movement to preserve biodiversity has been profound and far-reaching, as it represents proof of the potential value of natural products, and ...
Robert A. Newman, Dominic Fan
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2003
Introduction Taxoids are a family of diterpene alkaloids sharing a tricyclic taxane core (Figure 9.1A). The most well recognized member of the taxoid family is taxol (Figure 9.1B), a minor cytotoxic component isolated from yew bark (Wani et al., 1971).
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Introduction Taxoids are a family of diterpene alkaloids sharing a tricyclic taxane core (Figure 9.1A). The most well recognized member of the taxoid family is taxol (Figure 9.1B), a minor cytotoxic component isolated from yew bark (Wani et al., 1971).
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Immunoassay for the detection of taxoids
1998info:eu-repo/semantics ...
El Jaziri, Mondher +3 more
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Synthesis of Taxoids II. Synthesis and Antitumor Activity of Water-soluble Taxoids
HETEROCYCLES, 1997Tomiki Hashiyama +9 more
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