Results 151 to 160 of about 3,991 (207)
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Minor Taxoids from Taxus wallichiana
Journal of Natural Products, 1995The needles of Taxus wallichiana afforded a new analogue of taxinine M [1a] and two derivatives of brevifoliol [2a, 3a]. The conformation of 3a was investigated by nmr spectroscopy with the aid of variable-temperature experiments and in situ reactions.
BARBONI, Luciano +6 more
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Journal of Ethnopharmacology, 2003 Four taxoids (taxusin, baccatin VI,baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropyl ether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the ...
Erdem Yesilada +2 more
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The Chemistry of Taxol and Related Taxoids
2002The anticancer compound taxol (1.1.1) was originally isolated in the late 1960’s from the bark of the Western Yew, Taxus brevifolia, and its structure was published in 1971 in a paper that has been cited well over 1000 times since its publication (1). Taxol was originally isolated on the basis of its cytotoxicity and antileukemic activity, but it was ...
D G I, Kingston +3 more
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Fluorescent Taxoid Probes for Microtubule Research
2010The use of the antitumor drug taxol as an experimental microtubule-stabilizing agent is widespread. Fluorescent taxol conjugates, although less employed, are very useful tools for several purposes in microtubule research. These include easily visualizing microtubule cytoskeletons in a variety of cells as well as in vitro assembled microtubules ...
Barasoain, Isabel +2 more
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2000
Abstract A 70-year-old man was discovered to have melanoma of the right fifth toe. Following toe amputation, he was started on paclitaxel (250 mglm2 ) every 3 weeks, as part of a phase II clinical trial. He received 16 courses with clinical and radiographic disappearance of adenopathy.
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Abstract A 70-year-old man was discovered to have melanoma of the right fifth toe. Following toe amputation, he was started on paclitaxel (250 mglm2 ) every 3 weeks, as part of a phase II clinical trial. He received 16 courses with clinical and radiographic disappearance of adenopathy.
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ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Zhiyan Xiao +2 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Zhiyan Xiao +2 more
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Preclinical Evaluation of New Taxoids
Current Pharmaceutical Design, 2001Paclitaxel and docetaxel are two key molecules in the treatment of a variety of cancers with major impact in the treatment of breast, lung and ovarian cancers. A number of taxoids have then been synthesized in an effort to improve some of the features of the existing drugs.
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The scientific rationale for developing taxoids
Anti-Cancer Drugs, 1996The taxoid drugs, docetaxel (Taxotere) and paclitaxel (Taxol), represent a new class of antitumour agents which act by promoting the assembly and inhibiting the disassembly of microtubules. Docetaxel has been shown to be more potent than paclitaxel with regard to the formation and stabilization of microtubules in vitro. Docetaxel also has a higher cell
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Tetrahedron Letters, 1993
Abstract The aldol condensation of the ketone 6 and the aldehyde 7 followed by an annelation-fragmentation afforded the bicyclo[6.4.0]dodecane derivative 3 with the appropriate functionalities for further elaboration.
S. Arseniyadis +6 more
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Abstract The aldol condensation of the ketone 6 and the aldehyde 7 followed by an annelation-fragmentation afforded the bicyclo[6.4.0]dodecane derivative 3 with the appropriate functionalities for further elaboration.
S. Arseniyadis +6 more
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Tetrahedron, 1994
Abstract [2+2] Photocycloadditions between enone 2 and 2,3-dihydropyran derivatives lead to a number of interesting intermediates 3a–e for taxoid ...
Siegfried Blechert +2 more
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Abstract [2+2] Photocycloadditions between enone 2 and 2,3-dihydropyran derivatives lead to a number of interesting intermediates 3a–e for taxoid ...
Siegfried Blechert +2 more
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