Results 171 to 180 of about 31,972 (221)
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Chemotherapy, 2000
<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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Pharmacology & Therapeutics, 1991
Abstract The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.
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Abstract The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.
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Immunoassay of taxol and taxol-like compounds in plant extracts
Life Sciences, 1993A mouse monoclonal anti-taxol antibody (69E4A8E) and a rabbit polyclonal anti-taxol antiserum were used to measure taxol levels in plant extracts in a double-blind experiment in conjunction with assays by HPLC. 69E4A8E was previously shown by ELISA to be specific for taxol with only a slight cross reaction with another bioactive compound ...
J G, Leu +4 more
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Journal of Medicinal Chemistry, 2006
T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain.
Ana A, Alcaraz +3 more
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T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain.
Ana A, Alcaraz +3 more
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Blood, 2007
In this issue of Blood , Janssen and colleagues report the essential role of apoptosome formation for taxol-induced apoptosis and suggest a role for Apaf-1 and caspase-9 in tumor development. There have been contrasting reports regarding the role of caspase-9 and Apaf-1 for tumor development ...
Yousefi, Shida, Simon, Hans-Uwe
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In this issue of Blood , Janssen and colleagues report the essential role of apoptosome formation for taxol-induced apoptosis and suggest a role for Apaf-1 and caspase-9 in tumor development. There have been contrasting reports regarding the role of caspase-9 and Apaf-1 for tumor development ...
Yousefi, Shida, Simon, Hans-Uwe
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Phytochemistry, 2001
The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
K, Walker, R, Croteau
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The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
K, Walker, R, Croteau
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The Journal of Organic Chemistry, 1993
Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than taxol to P-388 ...
Ashok G. Chaudhary +2 more
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Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than taxol to P-388 ...
Ashok G. Chaudhary +2 more
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Nature, 1994
Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provided one of the most significant advances in cancer therapy, this molecule exerts its anticancer activity by inhibiting mitosis through enhancement ...
K. C. Nicolaou +10 more
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Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provided one of the most significant advances in cancer therapy, this molecule exerts its anticancer activity by inhibiting mitosis through enhancement ...
K. C. Nicolaou +10 more
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The transport and binding of taxol
General Pharmacology: The Vascular System, 19971. This review brings together the information available to date regarding how taxol cytotoxicity and the development of resistance to this drug is affected by its cellular transport and intracellular binding. 2. Taxol, a potent anticancer drug first extracted from the bark of the Pacific yew tree, is extremely effective in the treatment of a wide ...
H, Parekh, H, Simpkins
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Cancer, 1993
AbstractTaxol is a structurally complex natural plant product with a novel mechanism of action. The supply of this drug is limited by its low abundance in the bark of the slow‐growing yew tree from which it is extracted. The chemical complexity of taxol has hampered the development of a feasible process to synthesize large quantities.
C D, Runowicz +4 more
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AbstractTaxol is a structurally complex natural plant product with a novel mechanism of action. The supply of this drug is limited by its low abundance in the bark of the slow‐growing yew tree from which it is extracted. The chemical complexity of taxol has hampered the development of a feasible process to synthesize large quantities.
C D, Runowicz +4 more
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