Results 181 to 190 of about 31,972 (221)
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The Journal of Organic Chemistry, 2000
Numerous structure-activity studies combining synthesis and bioassay have been performed for the anti-cancer drug Taxol. The four-membered D-ring, an oxetane, is one of four structural features regarded to be essential for biological activity.
M, Wang +4 more
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Numerous structure-activity studies combining synthesis and bioassay have been performed for the anti-cancer drug Taxol. The four-membered D-ring, an oxetane, is one of four structural features regarded to be essential for biological activity.
M, Wang +4 more
openaire +2 more sources
Annual Review of Plant Physiology and Plant Molecular Biology, 1994
P F Heinstein, C J Chang
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P F Heinstein, C J Chang
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Taxol-producing Fungi: A New Approach to Industrial Production of Taxol
Chinese Journal of Biotechnology, 2006Produced by and purified from Taxus brevifolia, Taxol (paclitaxel) has become a widely used cancer drug in clinic. Due to the rapid growing market, current industrial production of taxol by semi-synthesis that consumes large amount of Taxus trees cannot meet the requirement of the market.
Yuan, Ji +3 more
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Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes
Pharmaceutical Research, 1994Taxol is a promising anticancer agent under investigation for therapy of ovarian, breast, colon, and head and neck cancer. One problem associated with the administration of taxol is its low solubility in most pharmaceutically-acceptable solvents; the formulation used clinically contains Cremophor EL (polyethoxylated castor oil) and ethanol as ...
A, Sharma, R M, Straubinger
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Neurotoxicity of cisplatin and taxol
International Journal of Gynecological Cancer, 1995Since the discovery of the activity of cisplatin in ovarian cancer approximately 15 years ago, there has been little progress in improving survival for patients with this disease. Thus there has been great enthusiasm in the gynecologic oncology community over the results of GOG111, the Gynecologic Oncology Group (GOG) study randomizing suboptimally ...
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Novel Taxol formulations: Taxol-containing liposomes.
Journal of the National Cancer Institute. Monographs, 1994Taxol is a complex diterpenoid natural product under investigation for therapy of colon, ovarian, lung, and breast cancer, as well as for melanoma and lymphoma. One problem associated with the administration of Taxol is its low solubility; the formulation used clinically contains polyethoxylated castor oil (Cremophor EL) and ethanol as excipients ...
R M, Straubinger +3 more
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