Results 181 to 190 of about 58,325 (234)
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1994
Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting it from its natural source ...
D R, Kohler, B R, Goldspiel
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Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting it from its natural source ...
D R, Kohler, B R, Goldspiel
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Chemotherapy, 2000
<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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Angewandte Chemie International Edition in English, 1995
AbstractMuch has been written about taxol, one of the newest weapons against cancer, and its producer, the Pacific Yew tree (Taxus brevifolia).K. C. Nicolaou, W.‐M. Dai, R. K. Guy, Angew. Chem. 1994, 106, 38–69; Angew. Chem. Int. Ed. Engl. 1994, 33, 15–44.
R. K. Guy, Kyriacos C. Nicolaou
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AbstractMuch has been written about taxol, one of the newest weapons against cancer, and its producer, the Pacific Yew tree (Taxus brevifolia).K. C. Nicolaou, W.‐M. Dai, R. K. Guy, Angew. Chem. 1994, 106, 38–69; Angew. Chem. Int. Ed. Engl. 1994, 33, 15–44.
R. K. Guy, Kyriacos C. Nicolaou
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ChemInform Abstract: Total synthesis of taxol.
ChemInform, 1994AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erik J. Sorensen +12 more
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Tetrahedron Letters, 2001
Abstract Bioconversion of taxol/cephalomannine by Streptomyces sp. MA 7065 resulted in hydroxylation on the 10-acetyl methyl group in 60% yield and on the benzene ring at the para position of the phenylisoserine side chain in 10% yield.
Yeuh-chuen Liu +4 more
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Abstract Bioconversion of taxol/cephalomannine by Streptomyces sp. MA 7065 resulted in hydroxylation on the 10-acetyl methyl group in 60% yield and on the benzene ring at the para position of the phenylisoserine side chain in 10% yield.
Yeuh-chuen Liu +4 more
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Pharmacology & Therapeutics, 1991
Abstract The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.
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Abstract The chemistry of the potent anticancer diterpenoid taxol is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships.
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Immunoassay of taxol and taxol-like compounds in plant extracts
Life Sciences, 1993A mouse monoclonal anti-taxol antibody (69E4A8E) and a rabbit polyclonal anti-taxol antiserum were used to measure taxol levels in plant extracts in a double-blind experiment in conjunction with assays by HPLC. 69E4A8E was previously shown by ELISA to be specific for taxol with only a slight cross reaction with another bioactive compound ...
Jyh-Gang Leu +4 more
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Phytochemistry, 2001
The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
Kevin Walker, Rodney Croteau
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The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta ...
Kevin Walker, Rodney Croteau
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Cancer, 1993
AbstractTaxol is a structurally complex natural plant product with a novel mechanism of action. The supply of this drug is limited by its low abundance in the bark of the slow‐growing yew tree from which it is extracted. The chemical complexity of taxol has hampered the development of a feasible process to synthesize large quantities.
Carolyn D. Runowicz +4 more
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AbstractTaxol is a structurally complex natural plant product with a novel mechanism of action. The supply of this drug is limited by its low abundance in the bark of the slow‐growing yew tree from which it is extracted. The chemical complexity of taxol has hampered the development of a feasible process to synthesize large quantities.
Carolyn D. Runowicz +4 more
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Taxol-producing Fungi: A New Approach to Industrial Production of Taxol
Chinese Journal of Biotechnology, 2006Produced by and purified from Taxus brevifolia, Taxol (paclitaxel) has become a widely used cancer drug in clinic. Due to the rapid growing market, current industrial production of taxol by semi-synthesis that consumes large amount of Taxus trees cannot meet the requirement of the market.
Xudong Zhu +3 more
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