Results 191 to 200 of about 58,325 (234)
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Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes
Pharmaceutical Research, 1994Taxol is a promising anticancer agent under investigation for therapy of ovarian, breast, colon, and head and neck cancer. One problem associated with the administration of taxol is its low solubility in most pharmaceutically-acceptable solvents; the formulation used clinically contains Cremophor EL (polyethoxylated castor oil) and ethanol as ...
Amarnath Sharma, Robert M. Straubinger
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The Journal of Organic Chemistry, 1993
Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than taxol to P-388 ...
Ashok G. Chaudhary +2 more
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Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than taxol to P-388 ...
Ashok G. Chaudhary +2 more
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ChemInform Abstract: The Oxetane Ring in Taxol.
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
James H. Nettles +4 more
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The transport and binding of taxol
General Pharmacology: The Vascular System, 19971. This review brings together the information available to date regarding how taxol cytotoxicity and the development of resistance to this drug is affected by its cellular transport and intracellular binding. 2. Taxol, a potent anticancer drug first extracted from the bark of the Pacific yew tree, is extremely effective in the treatment of a wide ...
Hemant K. Parekh, Henry Simpkins
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From taxol to taxol®: The changing identities and ownership of an anti-cancer drug
Medical Anthropology, 2002This paper analyzes the emergence and evolution of taxol, the world's bestselling anti-cancer drug. Over the years taxol has changed its identity, its status as property, and its association with different places (from the old-growth forests of Washington State to the government agencies of Washington, D.C., to laboratories in France).
Jordan, Goodman, Walsh, V.
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The photochemistry of taxol: Synthesis of a novel pentacyclic taxol isomer
Tetrahedron Letters, 1992Abstract Photolysis of taxol with 254 nm UV light is found to be a very effective method to prepare a novel taxol analog featuring a Carbon-Carbon bond between C 3 and C 11 .
Susan E. Hill +4 more
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ChemInform Abstract: Chemistry and Biology of Taxol
ChemInform, 1994AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kyriacos C. Nicolaou +3 more
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Angewandte Chemie International Edition in English, 1995
Abstract Discussion Points What is the mechanism of step a? What is the purpose of aluminium triisopropoxide in step b? Give reasons for the selectivity (4:1) obtained in the osmylation step c. When fluoride ion was used instead of ethylene glycol as the desilylating agent to promote the formation of the oxetane ring in 3, the main ...
L. B. Snyder +4 more
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Abstract Discussion Points What is the mechanism of step a? What is the purpose of aluminium triisopropoxide in step b? Give reasons for the selectivity (4:1) obtained in the osmylation step c. When fluoride ion was used instead of ethylene glycol as the desilylating agent to promote the formation of the oxetane ring in 3, the main ...
L. B. Snyder +4 more
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Neurotoxicity of cisplatin and taxol
International Journal of Gynecological Cancer, 1995Since the discovery of the activity of cisplatin in ovarian cancer approximately 15 years ago, there has been little progress in improving survival for patients with this disease. Thus there has been great enthusiasm in the gynecologic oncology community over the results of GOG111, the Gynecologic Oncology Group (GOG) study randomizing suboptimally ...
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Effect of nitric oxide on cytotoxicity of Taxol: enhanced Taxol transcellular permeability
Biochemical Pharmacology, 2003The present studies were aimed at testing the hypothesis that nitric oxide (NO) may enhance Taxol-induced cytotoxicity in carcinoma cells by increasing influx of Taxol into intracellular compartments. Prostate carcinoma cells (PC-3, LNCaP) and neuroblastoma cells (SKNDZ, CHP212) were used to investigate both transmembrane permeability and cytotoxicity ...
Yao Wang +5 more
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