Results 161 to 170 of about 174,907 (264)

Chlamydiae in cnidarians: Shared functional potential despite broad taxonomic diversity

, 2023
Maire J, Collingro A, Horn M, van Oppen MJH.   +3 more
europepmc   +1 more source

Taxonomic Diversity and Morphological Disparity of Paleozoic Ammonoids [PDF]

, 2015
Korn, Dieter, Klug, Christian, Walton, Sonny A   +2 more
openaire   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Taxonomic Diversity of <i>Ranunculus</i> Section <i>Ranunculastrum</i> (Ranunculaceae) in Tajikistan, With an Identification Key and a New Species Based in Part on Molecular Phylogenetic Evidence. [PDF]

Ecol Evol
Erst AS, Boboev MT, Boboev KM, Baasanmunkh S, Sharples MT, Kuznetsov AA, Kulikovskiy MS, Kostikova VA, Maltseva SY, Erst TV, Skaptsov MV, Xiang K, Lian L, Choi HJ, Wang W.   +14 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Taxonomic diversity and abundance of enchytraeids (Annelida, Clitellata, Enchytraeida) in the Northern Palaearctic. 2. European Russia. [PDF]

Biodivers Data J
Saifutdinov RA, Degtyarev MI, Korobushkin DI, Artemieva SM, Byzov PS, Danilova MA, Ditts AA, Ermokhina KA, Garibian PG, Gorbunova AY, Guseva PA, Karlik EI, Kondratieva TY, Kupriyanov DA, Lebedev IM, Lebedeva NV, Nazarov PA, Neplyukhina AA, Noskova EA, Obolensky RR, Panchenkov AA, Popova AV, Pronina NA, Rüthi J, Schaepman-Strub G, Shakhab SV, Zaitsev AS, Zemlianskii VA, Zvychaynaya EY, Gongalsky KB.   +29 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Fine-Scale Variation in Soil Properties Promotes Local Taxonomic Diversity of Hybridizing Oak Species (Quercus spp.). [PDF]

Evol Appl
Zimmermann F, Reutimann O, Baltensweiler A, Walthert L, Olofsson JK, Rellstab C.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Taxonomic diversity of microbial communities in the cold sulfur spring Bezymyanny (Pribaikalsky district, Republic of Buryatia). [PDF]

Vavilovskii Zhurnal Genet Selektsii
Banzaraktsaeva TG, Lavrentyeva EV, Dambaev VB, Ulzetueva ID, Khakhinov VV.   +4 more
europepmc   +1 more source