Rewiring transcriptional plasticity: the case for dual YAP1 and TAZ targeting in gastric cancer peritoneal metastases. [PDF]
Kumar R.
europepmc +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Targeting eIF4A-dependent translation in genetically complex sarcoma. [PDF]
Kim YM +16 more
europepmc +1 more source
Mechanical intelligence reframes bone regeneration as a time‐dependent coupling between material and cellular memory. Biomaterials store and release mechanical history, while cells retain prior cues and remodel the repair niche. Matching these memories to healing stages may guide stage‐specific scaffolds, sensing‐assisted prediction, mechanical dosing,
Jin Tian +8 more
wiley +1 more source
The mechano-immunological landscape in the tumor microenvironment: From mechanical sensing to a new therapeutic paradigm. [PDF]
Li W, Xin YY, Jin MZ, Jin WL.
europepmc +1 more source
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei +2 more
wiley +1 more source
Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP/TAZ. [PDF]
Cruz-Soca M +14 more
europepmc +1 more source
The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution
p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz +3 more
wiley +1 more source
Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial. [PDF]
Benítez-Cano A +15 more
europepmc +1 more source

